Project Grant R16GM165987
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $123,147 on August 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how cellular biophysical and biochemical environments reshape fatty acid synthase (FASN) structure and function in disease contexts. The recipient will employ CRISPR-based endogenous tagging, cryo-electron microscopy and tomography, fluorescence imaging, and...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $384,394 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular determinants of lipid-protein recognition through computational and experimental approaches. The research integrates deep-learning, molecular dynamics simulation, and de novo protein design to characterize biophysical interactions governing binding affinity and...
- The National Institute of General Medical Sciences awarded The University Corporation $405,625 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover and characterize thermoregulatory RNA elements in bacteria, phages, chloroplasts, and mitochondria. The funded work expands discovery and characterization of thermoregulatory RNAs—structured RNA elements that respond to heat stress—across prokaryotic and organellar genomes over five years. A major...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $369,347 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct high-resolution structural analysis of megasynthases by cryo-electron microscopy. The project develops molecular tools and probes to enable structural visualization of protein-protein interactions within carrier protein-dependent biosynthetic pathways, including fatty acid synthase,...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $440,750 on June 1, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on novel cholesterol-protein interactions in cholesterol-producing and cholesterol-utilizing bacteria. The research focuses on understanding sterol lipid biosynthesis, function, regulation, and transport in microbial systems, with particular emphasis on bacterial cholesterol...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded the University of California, Davis $1.624736 million under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026. The award funds research into morphological reprogramming of the endoplasmic reticulum by cellular mucins. The project tests the hypothesis that transmembrane mucins act as membrane curvature generators on the luminal face of the endoplasmic...
- The National Institute of General Medical Sciences awarded The Regents of the University of California at Riverside $399,391 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct molecular modeling and theoretical characterization of protein dynamics and ligand binding. The research develops and applies molecular dynamics simulation techniques to understand protein-ligand binding at atomic detail, with emphasis on binding kinetics, binding residence...
The National Institute of General Medical Sciences awarded the University Enterprises Corporation at California State University, San Bernardino $183,750 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research on the mechanisms of long-chain fatty acid transport through the FADL protein in Escherichia coli. The research addresses knowledge gaps in how the FADL transporter, an outer membrane protein in gram-negative bacteria, recognizes and translocates long-chain fatty acids and other hydrophobic substrates. The work employs substituted cysteine accessibility method and disulfide crosslinking to analyze plug domain dynamics and determine whether conformational rearrangement is required for transport. Site-directed chemical crosslinking with bifunctional crosslinkers will test whether accessibility of the lateral opening in the barrel wall is functionally linked to fatty acid translocation. The research also aims to identify specific amino acid side chains critical for substrate binding. The award covers the period from August 15, 2026, through April 30, 2030, with performance at Verdemont, California. The assistance type is Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $183.8k | 8/5/26 |