Project Grant R16GM159791
- The National Institute of General Medical Sciences awarded the University of Tennessee $413,069 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on spatial regulation of plasma membrane signaling through super-resolution fluorescence imaging. The research focuses on how receptor signaling complexes are assembled and regulated by heterogeneous membrane structure in T cells, specifically examining T cell receptor activation and...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $407,603 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate brain-body allostasis via longitudinal in vivo imaging. The research examines how astrocytes—non-neuronal glial cells in the brain—coordinate physiological state shifts and facilitate whole-body allostasis during stress response. The study uses simultaneous in vivo recording of...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Boston Children's Hospital $674,950 on January 16, 2026, to dissect neural circuits that mediate top-down control of sympathetic nervous system functions under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Boston Children's Hospital will conduct basic neuroscience research analyzing...
- The National Institute of General Medical Sciences awarded the University of Tennessee $406,112 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to pioneer mass spectrometry-based footprinting techniques that reveal human integral membrane protein structures in native membranes and tissues. The research addresses a critical gap in understanding higher-order structure and function of integral membrane proteins under physiological conditions....
- The National Heart, Lung, and Blood Institute awarded East Tennessee State University $536,447 under the Cardiovascular Diseases Research program (CFDA 93.837) on August 15, 2026, to investigate mechanisms of macrophage retention in the extracellular matrix during atherosclerosis development. The project examines how oxidation of polyunsaturated fatty acids—including docosahexaenoic acid, arachidonic acid, and linolenic acid—generates adhesive substrates in vascular tissue that anchor...
- The National Heart, Lung, and Blood Institute awarded the University of California, San Diego $799,256 on June 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate cardiac protection through neuromodulation after myocardial infarction. The project, designated R01HL183128, will conduct research on the interplay between cardiac injury signals, brain integration, and peripheral sympathetic outflow following myocardial infarction. The work spans three...
- The National Institute of General Medical Sciences awarded Yale University $922,854 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop scalable statistical methods for inferring interactions within large biological networks and to apply these methods to neural activity and chromatin structure. The research will leverage recordings of thousands of neurons in the mouse hippocampus and visual system to identify networks of neural interactions...
- The National Heart, Lung, and Blood Institute awarded Cincinnati Children's Hospital Medical Center $128,589 on September 27, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the contribution of JNK signaling to exercise pressor reflex dysfunction in primary hypertension. The research tests the hypothesis that enhanced JNK signaling in dorsal root ganglia of hypertensive mice occurs through increased peripheral tumor necrosis factor-alpha, resulting in...
- The National Institute of General Medical Sciences awarded East Tennessee State University $250,000 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to acquire a liquid-chromatography tandem mass spectrometry (LC-MS/MS) system. The instrument will support biomedical research and educational initiatives across the university's Academic Health Science Center, primarily serving researchers and students in the Colleges of Medicine and Pharmacy, with access...
- The National Heart, Lung, and Blood Institute awarded the University of Virginia $721,977 on August 25, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to uncover the molecular and functional organization of cardiovagal neurons that regulate heart rate through the vagus nerve. The project will map the synaptic inputs, outputs, and functional sufficiency of two distinct cardiovagal neuron subtypes—NPY2R-expressing neurons in the nucleus ambiguus and VIP-expressing neurons...
The National Institute of General Medical Sciences awarded East Tennessee State University a $152,000 Project Grant (CFDA 93.859, Biomedical Research and Research Training) on August 15, 2026, to characterize the role of the central amygdala and hypothalamic paraventricular nucleus in stress-augmented cardiogenic sympathetic afferent reflex in rats. The research uses optogenetics to inhibit activation of rostral ventrolateral medulla-projecting neurons from these brain regions and assesses the effect on renal sympathetic nerve activity, heart rate, and blood pressure following epicardial bradykinin application to model ischemic events. The work addresses how chronic stress over-activates the sympathetic nervous system and augments the dangerous sympathetic reflex triggered by myocardial ischemia, with implications for understanding stress-related hypertension and cardiac complications. Performance occurs in Johnson City, Tennessee, with a period of performance through April 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $152.0k | 8/5/26 |