Project Grant R16GM159165
- This federal Project Grant award of $545,759 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research to determine whether and how enhancing serotonin transmission in the mouse infralimbic medial prefrontal cortex during adolescence can suppress activity in somatostatin neurons and enhance fear extinction in adolescents and adults. This research aims to improve understanding of the serotonin-mediated...
- This federal Project Grant award of $743,045 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to the Oregon Health & Science University (OHSU). The grant aims to study the long-term consequences of extinction enhancement in a model of post-traumatic stress disorder (PTSD) and its comorbidities. Specifically, the research will evaluate the persistent effects of acute systemic administration of histone deacetylase...
- The National Institute of General Medical Sciences (NIGMS) awarded a $248,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University on August 28, 2025. The project, titled "Stress Response Signaling as a Metabolic Sensor in Reproduction," aims to examine how nutrient sensing alters reproductive capacity via the integrated stress response (ISR) signaling pathway and steroid hormones in the Drosophila model organism. The research...
- This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to investigate sex differences in the impact of prenatal stress on cognitive dysfunction and resilience to stress. The $711,361 award to Loyola University of Chicago, Health Sciences Campus will support a 5-year study to determine if RNA editing of the GluA2 subunit of the AMPA glutamate receptor mediates the long-term detrimental effects...
- This $382,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by Washington State University (WSU) into the molecular and neural mechanisms that regulate stress responses. The research focuses on how organisms deploy appropriate stress responses to counter internal and external threats, and how neural circuits can attenuate overreactive stress responses to...
- This federal Project Grant award of $719,917 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to study the effects of chronic stress on cognitive flexibility. The primary awardee, The Medical College of Wisconsin, Inc., will examine how chronic stress increases REDD1 expression in the prefrontal cortex, leading to disruptions in dendritic spine structure and function in pyramidal neurons that project to the nucleus...
- This Project Grant award of $359,433 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the protein FKBP51 in modulating serotonergic function and fear responses. The research aims to increase or decrease FKBP51 expression in serotonin neurons to study its effects on fear learning and extinction. The project will also use a novel serotonin biosensor to measure serotonin release in the...
- This federal Project Grant award of $406,073 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research to investigate the impacts of hormonal contraceptives on fear behavior, neurocircuitry, and the gut microbiome. The goal is to improve understanding of the biological mechanisms underlying the psychiatric side effects of hormonal contraceptives, and develop strategies to identify women at risk and improve...
- This Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides funding of $390,000.00 to the University of Texas Health Science Center at Houston (UTHealth) to conduct research on hypothalamic prodynorphin neurocircuits and their role in integrating defensive behaviors. The project aims to elucidate the brain mechanisms underlying anxiety disorders such as post-traumatic stress disorder (PTSD), with a focus on understanding how...
- This federal Project Grant award, valued at $372,880 and issued on May 1, 2025, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project aimed at understanding how cells regulate protein synthesis to maintain homeostasis during cellular stress. The key focus is on investigating the role of the translation initiation factor eIF2 and its phosphorylation in modulating gene...
The Project Grant award titled "PREFRONTAL MODULATORS OF STRESS-INDUCED EXTINCTION IMPAIRMENT IN FEMALE RATS" is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $156,000 award to the Ponce Medical School Foundation Inc. in Puerto Rico aims to examine the role of the infralimbic cortex proteins neurogranin and microtubule associated protein tau (MAPT) in susceptibility to impaired fear extinction in female rats after exposure to traumatic stress. The goal is to further validate the preliminary proteomic findings and understand how these prefrontal mechanisms may contribute to altered susceptibility to impaired extinction in females. The project will be conducted over a period of 4 years from August 1, 2025 to July 31, 2029.