Project Grant R01MH140412
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $770,654 to the University of Texas at Austin to conduct research on the efficacy and mechanisms of exercise-enhanced fear extinction in individuals with post-traumatic stress disorder (PTSD). The goal is to establish how different intensities of exercise delivered after fear extinction learning can impact the retrieval and generalization...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $424,175 to Virginia Commonwealth University (VCU) to conduct research aimed at understanding the genomic basis of post-traumatic stress disorder (PTSD). The study will leverage existing large-scale whole exome and whole genome sequencing datasets and biorepositories to identify additional genetic signals for PTSD by integrating rare variants...
- This federal Project Grant award of $545,759 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research to determine whether and how enhancing serotonin transmission in the mouse infralimbic medial prefrontal cortex during adolescence can suppress activity in somatostatin neurons and enhance fear extinction in adolescents and adults. This research aims to improve understanding of the serotonin-mediated...
- This Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides funding of $390,000.00 to the University of Texas Health Science Center at Houston (UTHealth) to conduct research on hypothalamic prodynorphin neurocircuits and their role in integrating defensive behaviors. The project aims to elucidate the brain mechanisms underlying anxiety disorders such as post-traumatic stress disorder (PTSD), with a focus on understanding how...
- This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a research project titled "AUGMENTING COGNITIVE PROCESSING THERAPY WITH A PEER-LED SUPPORT INTERVENTION TO IMPROVE WELL-BEING: A SUSTAINABLE AND SCALABLE MODEL FOR ENHANCING PTSD RECOVERY IN VULNERABLE POPULATIONS." The $567,000 award to Trustees of Boston University's Medical Campus will support the development and evaluation of a model...
- This Project Grant award of $180,439 from the National Institute of Mental Health (NIMH), under the CFDA program "Mental Health Research Grants", will support new mentored training in the computational neuroscience of higher-order threat learning and memory in post-traumatic stress disorder (PTSD) for the award recipient as they transition to an independent research faculty role. The objective is to build on the recipient's functional MRI training and incorporate new training in...
- This $769,753 federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to leverage large-scale multimodal neuroimaging datasets to identify neural biomarkers and biotypes underlying post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety disorders (ANXs). The research project, with an award period from Jul 21, 2025 to Apr 30, 2030, will utilize explainable deep learning...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $610,152 to Duke University to study the structural and functional architecture of cortico-cerebellar systems in post-traumatic stress disorder (PTSD). The key objectives are to investigate the influence of PTSD, trauma exposure, and PTSD symptom clusters on the functional connectivity of cerebellar subregions to cortical and subcortical regions,...
- The Project Grant award titled "PREFRONTAL MODULATORS OF STRESS-INDUCED EXTINCTION IMPAIRMENT IN FEMALE RATS" is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $156,000 award to the Ponce Medical School Foundation Inc. in Puerto Rico aims to examine the role of the infralimbic cortex proteins neurogranin and microtubule associated protein tau (MAPT) in susceptibility to impaired fear...
- This federal Project Grant award of $158,246.00 from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, will support research under the Drug Use and Addiction Research Programs (CFDA 93.279). The award will fund a comprehensive, longitudinal study investigating the co-occurrence of trauma, substance use, and additional stressors among Americans from childhood through adulthood. The research aims to elucidate the etiological trajectories of co-occurring...
This federal Project Grant award of $743,045 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to the Oregon Health & Science University (OHSU). The grant aims to study the long-term consequences of extinction enhancement in a model of post-traumatic stress disorder (PTSD) and its comorbidities. Specifically, the research will evaluate the persistent effects of acute systemic administration of histone deacetylase (HDAC) inhibitors, which may promote a more robust and enduring form of extinction learning, on appetitive behaviors that are persistently altered by stress. This innovative work seeks to fill a key gap in understanding how enhanced extinction effects operate in a PTSD model with comorbid reward/motivation disorders. The award has an initial performance period from Sep 20, 2025 to Aug 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $743.0k | 9/20/25 |