Project Grant R16GM158919
- The National Institute of General Medical Sciences awarded The Regents of the University of California at Riverside $420,492 on July 10, 2026, as a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemical synthesis strategies targeting underexplored protein receptors associated with cancer, Alzheimer's disease, and inflammatory disorders. The five-year research program (performance through April 30, 2031) focuses on three therapeutic axes:...
- The National Institute of General Medical Sciences awarded the University of California Irvine $526,832 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance stereoselective synthesis methods inspired by natural products. The award is a Project Grant designated R35GM163463 with performance through May 31, 2031, at the Irvine, California campus. The funded research develops novel organic synthesis reactions designed to enable discovery of natural...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $420,981 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop engineered enzymatic catalysts for asymmetric hydrogen atom transfer reactions in synthetic chemistry. The research integrates organic chemistry, protein engineering, bioinorganic chemistry, and computational modeling to design and evolve biocatalysts that enable...
- The National Institute of General Medical Sciences awarded California Institute of Technology $225,564 on January 20, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an enantioselective dearomative cyclization strategy for synthesizing quinolizidine natural products. The research focuses on converting pyridine into enantioenriched quinolizidines in a single synthetic step using palladium catalysis and dynamic kinetic resolution. High-throughput data...
- The National Institute of General Medical Sciences awarded the University of California Irvine $365,267 on July 1, 2026, to investigate the structural and biochemical basis of NLRP3-mediated innate immune signaling under the Biomedical Research and Research Training program (CFDA 93.859). The project examines how the innate immune receptor NLRP3 recognizes and processes oxidized mitochondrial DNA (ox-mtDNA) to trigger inflammasome assembly. Aberrant NLRP3 activation contributes to chronic...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $369,347 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct high-resolution structural analysis of megasynthases by cryo-electron microscopy. The project develops molecular tools and probes to enable structural visualization of protein-protein interactions within carrier protein-dependent biosynthetic pathways, including fatty acid synthase,...
- The National Institute of General Medical Sciences awarded the University of California, Irvine $126,489 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods integrating physics-based and machine learning approaches for accelerated drug discovery. The project addresses the high cost and extended timelines of small-molecule drug development by combining molecular dynamics-based binding free energy calculations with active...
- The National Institute of General Medical Sciences, a bureau of the National Institutes of Health within the Department of Health and Human Services, awarded $301,936 to the University of California, Los Angeles on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds data-science-guided study and design of phosphoranyl radical-mediated reactions for the discovery of novel pharmaceutical compounds. The research builds a comprehensive,...
- The National Institute of Allergy and Infectious Diseases awarded San Diego State University Foundation $162,360 on November 26, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate NF-κB pathway roles in innate immune discrimination using the marine annelid Hydroides elegans. The project will elucidate how NF-κB homologs mediate beneficial versus pathological immune responses through three integrated aims: spatial gene expression mapping, functional...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $226,560 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop new catalytic methods for modular synthesis of saturated, nitrogen-containing heterocycles guided by mechanism-aware machine learning models. The research addresses a bottleneck in active pharmaceutical ingredient (API)...
The National Institute of General Medical Sciences awarded the California State University Long Beach Research Foundation $146,819 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop synthetic approaches for preparing arylated bioactive dihydrobenzofurans that modulate immune response. The project synthesizes five natural products—maceneolignan A, maceneolignan B, licarin A, licarin B, and acuminatin—and their structural analogs through optimization of a nickel-catalyzed cross-coupling reaction using bench-stable N-hydroxyphthalimide esters and aryl iodides as coupling reagents. This divergent synthetic strategy reduces the number of steps required to prepare structural analogs and enables late-stage diversification. The dihydrobenzofurans exhibit anti-inflammatory, anticancer, antiviral, and antifungal activity, with maceneolignan A demonstrated to inhibit chemokine receptor signaling implicated in allergic reactions, asthma, arthritis, inflammatory bowel disease, multiple sclerosis, and Alzheimer's disease. Synthesized compounds will be evaluated for their potential to modulate immune response in macrophage cell lines through collaboration with the Fraser Lab at California State University, Long Beach. Performance occurs in Long Beach, California, with a period of performance ending March 31, 2030. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $146.8k | 8/7/26 |