The National Institute of General Medical Sciences (NIGMS) awarded a $528,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research located in New York, NY. The purpose of this 4-year grant, with a period of performance from September 30, 2024 to July 31, 2028, is to develop novel approaches to map the folding and protein occupancy of entire chromosomes with single-nucleosome resolution and single-molecule precision. The...
The National Institute of General Medical Sciences (NIGMS) awarded a $651,001 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center in Dallas, TX. The grant will fund research to reveal the allosteric logic of the tubulin conformation cycle and provide new biochemical insights into microtubule stability by studying newly identified tubulin mutations. The project will also use single-molecule observations to define and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $534,160 to the Sloan-Kettering Institute For Cancer Research to support their research on the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The goals of this 5-year research program are to elucidate the mechanisms by which...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $395,387 to support research on the molecular mechanisms driving fast amoeboid cell migration. The award aims to deconstructing this poorly understood, three-dimensional migration mode that is commonly used by invasive cancer cells. Over the next 5 years, the research will focus on understanding the cortical actin architectures,...
The National Institute of General Medical Sciences (NIGMS) awarded a $222,708 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Regents of the University of Michigan to support research on "Feedback Mechanisms Link Tubulin PTMs to Golgi Organization". The overarching goal is to define the mechanisms by which individual microtubules are identified and chosen in cells for specific post-translational modifications, and how mechanical cues drive these...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 - Biomedical Research and Research Training provides $440,000.00 over 5 years to the Sloan-Kettering Institute for Cancer Research to conduct research on the ubiquitin and autophagy signaling networks and their role in proteome homeostasis, or proteostasis. The research aims to uncover novel regulatory mechanisms of ubiquitin signaling and the underlying mechanisms of selective...
The National Institute of General Medical Sciences (NIGMS) awarded a $455,870 project grant (CFDA 93.859 Biomedical Research and Research Training) to the Research Foundation of the City University of New York (RFCUNY) doing business as RFCUNY - Brooklyn College. The award, titled "ENHANCING DRUG DISCOVERY RESEARCH BY FREE ENERGY MODELING," aims to expand the use of advanced computational binding free energy models for protein-drug interactions in academic and industrial drug discovery...
This $1,203,701 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to improve drug development by evaluating aspects of the drug development process. The award recipient, The Research Foundation For The State University Of New York, will utilize protein kinase inhibitors, specifically novel ATP-allosteric bivalent inhibitors (AABIs), to: Selectively target the inactive state of human...
This $383,891 Project Grant award from the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the mechanisms driving cell cycle plasticity and robustness. The principal investigator will use advanced time-lapse microscopy tools to investigate how cells can bypass inhibition of the CDK2 cell cycle regulator by activating alternative CDK4/6 pathways, enabling...
The National Institute of General Medical Sciences (NIGMS) awarded a $153,656 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Fred Hutchinson Cancer Center in Seattle, WA. The funding supports research to understand how post-translational modifications, specifically ubiquitin, contribute to kinetochore assembly and function in the budding yeast Saccharomyces cerevisiae. The research aims to generate a comprehensive map of kinetochore regulation by...