Project Grant R16ES038835
- The National Institute of Environmental Health Sciences awarded the University of Cincinnati $698,212 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate the impact of micro- and nanoplastics on cardiac toxicity and heart disease susceptibility. The research addresses mechanisms by which micro- and nanoplastics cause cardiac damage, focusing on mitochondrial dysfunction and oxidative stress in the heart. Preliminary findings show that exposure to micro- and...
- The National Institute of Environmental Health Sciences awarded New York University $10.907 million on September 15, 2025, under the Environmental Health program (CFDA 93.113) to conduct a translational study on the accumulation of micro- and nanoplastic particles in mammalian tissues. The research investigates inter-tissue accumulation of micro- and nanoplastic particles across the lifespan, including the quantified concentration of these particles within systemic tissues, the role of sex, age,...
- The National Institute of Environmental Health Sciences awarded the University of New Mexico Health Sciences Center $152,500 on August 15, 2026, under the Environmental Health program (CFDA 93.113) to define dose-response relationships and renal functional impairment from simultaneous exposure to micro- and nano-plastics and arsenic. The research establishes a quantitative framework for how micro- and nano-plastics behave when co-present with arsenic in the body, whether their excretion is...
- The National Institute of Environmental Health Sciences awarded $765,348 to the University of California, Davis on April 14, 2026, under the Environmental Health program (CFDA 93.113) to investigate pollutant-adsorbed nanoplastics and their health impacts following inhalation exposure. The research addresses the formation, distribution, and neurotoxic effects of composite particles created when airborne pollutants adsorb onto nanoplastics. The study employs advanced label-free imaging...
- The National Institute of Environmental Health Sciences awarded The University of Central Florida Board of Trustees $442,580 on September 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate microplastic-induced mechanobiological dysfunction in the vascular endothelium. The recipient will conduct a three-year study characterizing how microplastic exposure impairs endothelial cell mechanical integrity and function under physiologically relevant flow conditions. Aim 1...
- The National Institute of Environmental Health Sciences awarded Michigan State University $402,066 on September 27, 2025, under the Environmental Health program (CFDA 93.113) to investigate how the epicardium and the IRE1 signaling pathway mediate the effects of environmental chemical exposure on cardiac function. The project employs three-dimensional human heart organoids derived from induced pluripotent stem cells to model the impact of per- and polyfluoroalkyl substances (PFAS) on lipid...
- The National Institute of Environmental Health Sciences awarded New Jersey Institute of Technology $759,977 for a Project Grant (R56ES037652) on September 1, 2026, under the Environmental Health program (CFDA 93.113). The award funds investigation of placental translocation and toxicity of environmentally relevant nanoplastics—plastic particles smaller than one micron that accumulate in human organs and may disrupt health during sensitive developmental windows. NJIT will study placental toxicity...
- The National Institute of Environmental Health Sciences awarded Oklahoma State University $350,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the bioavailability and toxicity of microplastic and cadmium mixtures in the human gastrointestinal system and to develop undergraduate research training in interdisciplinary environmental science. The project examines how environmental weathering and digestive processes affect the sorption...
- The National Institute of Environmental Health Sciences awarded $114,072 to Rutgers The State University of New Jersey, School of Nursing, on September 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate mechanisms of micro-nanoplastics uptake, translocation, and toxicity in in vitro human intestinal models. The research explores how micro-nanoplastics—small plastic particles from environmental breakdown of waste—enter and cross biological barriers, particularly the...
- The National Institute of Environmental Health Sciences awarded Baylor College of Medicine $639,797 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to characterize the association between micro- and nanoplastic particle (MNP) exposure and preterm birth and to map the inflammatory and immunological mechanisms by which placental exposure to MNP drives adverse pregnancy outcomes. The research quantifies temporal patterns of MNP accumulation across 3,500 biospecimens (maternal...
The National Institute of Environmental Health Sciences awarded Morgan State University $142,399 on August 7, 2026, under the Environmental Health program (CFDA 93.113) to investigate the cardiac effects of weathered microplastics through aligned in vitro, ex vivo, and in vivo experimental systems. The research tests whether environmentally realistic weathered microplastics induce distinct and potentially more harmful biological effects on mammalian hearts than pristine microplastics. Foundational work with uniform polystyrene microplastics has demonstrated disruption of cardiomyocyte contractility, calcium handling, and electrophysiological stability at environmentally relevant concentrations; however, real-world microplastics are weathered through exposure to ultraviolet radiation, heat, hydrolysis, mechanical abrasion, and environmental chemicals, altering their physicochemical properties in ways that may fundamentally change toxicity. The project addresses a knowledge gap by exposing human induced pluripotent stem cell-derived cardiomyocytes and isolated adult mouse cardiomyocytes to both pristine and weathered microplastics to quantify particle uptake, contractility, and calcium transients across multiple biological systems. The period of performance runs from August 7, 2026, through July 31, 2030. Work is performed at Morgan State University in Baltimore, Maryland. This is a Project Grant, the assistance type under which NIEHS funds peer-reviewed research by named principal investigators.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $142.4k | 8/7/26 |