Project Grant R16ES038831
- The National Institute of Environmental Health Sciences awarded $400,398 to CSU Fullerton Auxiliary Services Corporation on April 7, 2026, under the Environmental Health program (CFDA 93.113) to investigate cellular and molecular mechanisms of bisphenol A-induced disruption of neurodevelopment. The project uses mouse and zebrafish models to understand how in utero exposure to bisphenol A disrupts neural development and to identify critical periods of dysfunction. The research employs...
- The National Institute of Environmental Health Sciences awarded $662,340 to the University of Massachusetts on August 13, 2026, under the Environmental Health program (CFDA 93.113) to investigate how per- and polyfluoroalkyl substances (PFAS) disrupt exocrine pancreas development and function in early life stages and identify recovery pathways through mechanistic study of the NRF2 pathway using transgenic zebrafish embryos. The research employs transgenic Danio rerio (zebrafish) embryos to...
- The National Institute of Environmental Health Sciences awarded $765,348 to the University of California, Davis on April 14, 2026, under the Environmental Health program (CFDA 93.113) to investigate pollutant-adsorbed nanoplastics and their health impacts following inhalation exposure. The research addresses the formation, distribution, and neurotoxic effects of composite particles created when airborne pollutants adsorb onto nanoplastics. The study employs advanced label-free imaging...
- The National Institute of Environmental Health Sciences awarded $760,000 to the University of California, San Diego on August 26, 2026, under the Environmental Health program (CFDA 93.113) for a Project Grant to develop a placenta-brain axis-on-a-chip platform for studying prenatal neurotoxicity. The recipient will construct a physiologically integrated human co-culture system coupling placental trophoblasts, maternal immune cells, fetal endothelial cells, and cortical organoids via...
- The National Institute of Environmental Health Sciences awarded Michigan State University $402,066 on September 27, 2025, under the Environmental Health program (CFDA 93.113) to investigate how the epicardium and the IRE1 signaling pathway mediate the effects of environmental chemical exposure on cardiac function. The project employs three-dimensional human heart organoids derived from induced pluripotent stem cells to model the impact of per- and polyfluoroalkyl substances (PFAS) on lipid...
- The National Institute of Environmental Health Sciences awarded the University of Rochester $1,433,378 on September 19, 2025, under the Environmental Health program (CFDA 93.113) to investigate airway basal cell stress mechanisms in environmentally-induced bronchiolitis obliterans following inhalation exposures to reactive diketones including diacetyl and 2,3-pentanedione. The research examines how chemical exposures damage cytoskeletal keratins in airway basal cells—the primary progenitor cells...
- The National Institute of Environmental Health Sciences awarded Drexel University $111,199 on April 3, 2026, under the Environmental Health program (CFDA 93.113) to investigate the role of phthalates, phenols, and their sources on phenotypic variability in autism and co-occurring neurodevelopmental disorders, obesity, and asthma. The recipient will use data from the Environmental Influences on Child Health Outcomes (ECHO) program, an NIH-funded consortium of longitudinal U.S.-based cohort...
- The National Institute of Environmental Health Sciences awarded the University of Southern California $1.256 million on April 10, 2026, under the Environmental Health program (CFDA 93.113) to conduct translational research on per- and polyfluoroalkyl substances (PFAS) and metabolic diseases. The award funds four interconnected research areas. Area 1 analyzes epidemiological data from over 50,000 participants across 18 diverse cohorts to examine PFAS associations with omics biomarkers and...
- The National Institute of Environmental Health Sciences awarded Duke University $444,125 on February 17, 2026, under the Environmental Health grant program (CFDA 93.113) to develop an integrated computational and experimental workflow for identifying endocrine-disrupting plastic additives using machine learning. The project pursues two aims. Aim 1 develops novel machine learning models trained on publicly available datasets to predict androgen receptor (AR) and estrogen receptor alpha (ERA)...
- The National Institute of Environmental Health Sciences awarded the University of Massachusetts $752,690 on August 13, 2026, for research on preconception and early pregnancy exposure to endocrine-disrupting chemicals under the Environmental Health grant program (CFDA 93.113). The project investigates how exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS), polybrominated diphenyl ethers (PBDEs), and trace elements affects women's reproductive health and the ability to achieve...
The National Institute of Environmental Health Sciences awarded the California State University Long Beach Research Foundation $138,202 on August 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate how calcium signaling disruption induced by environmental pollutants alters pancreatic cell function and glucose homeostasis. The project examines the role of the calcium-sensitive protein DREAM (Downstream Regulatory Element Antagonistic Modulator) in pancreatic health outcomes following exposure to polychlorinated biphenyls, bisphenol A, and tetrabromobisphenol A. The research uses zebrafish models—both wildtype and DREAM knockout strains—to detail the impact of calcium signaling disruption in pancreatic alpha and beta cells and connect cellular responses to organismal physiology. The Foundation's prior work in this area demonstrated that calcium signaling disruption exposure alters DREAM-regulated transcription in neuroendocrine cells and that pancreatic tissue displays greater toxicity markers than brain tissue in exposed organisms; many toxicity signs are reduced in DREAM knockout models. Current work will build on RNA sequencing data suggesting altered glucose homeostasis, intracellular calcium regulation, and cell cycle markers in pancreatic tissue. Performance occurs in Long Beach, California, with a period of performance from August 1, 2026, through July 31, 2030. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $138.2k | 7/31/26 |