Project Grant R15HL181586
- This federal Project Grant award of $747,281 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a real-time, non-invasive technique to characterize the mechanical properties of blood clots (thrombi) as they age. The project aims to utilize ultrasound-responsive nanodroplets that can transition into microbubbles when exposed to focused ultrasound, a process known as acoustic droplet vaporization (ADV). By leveraging ADV, the...
- This $165,980 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) supports a computational analysis of hemodynamics in patients with renal artery fibromuscular dysplasia (FMD). The goal is to investigate the impact of large vessel and small vessel disease on FMD versus atherosclerotic renal artery stenosis (ARAS) patients through hemodynamic indices like fractional flow reserve (FFR) and index of microvascular resistance...
- This federal Project Grant award of $110,635.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to characterize how red blood cell aggregation and membrane deformability affect endothelial cell injury and microvascular thrombosis in sepsis patients. The project will use microfluidics assays to analyze patient blood samples and apply machine learning to determine the impact of rheology on clinical outcomes. The research will also assess the...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) provides $640,562 to Duke University to develop advanced computer models that act as "virtual replicas" of a patient's blood vessels and heart activity. Using data from wearable sensors, the investigators will simulate how blood flows and interacts with vessel walls over time, enabling large-scale in silico testing of medical devices and therapies without...
- This $169,560 Project Grant was awarded on March 1, 2025 by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the Regents of the University of Michigan. The grant supports research to elucidate the role of the PERK/EIF2A/ATF4 endoplasmic reticulum stress response and MLL1-mediated CHOP expression in vascular smooth muscle cell apoptosis, with the goal of identifying therapeutic targets to limit abdominal aortic aneurysm (AAA) expansion. The research...
- The federal Project Grant award by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $534,761 to the University of California, Los Angeles (UCLA) to develop "Magnetoelastic Vascular Grafts" (MVGs). The MVGs are a transformative platform technology that can wirelessly and continuously monitor blood flow and detect stenosis (narrowing) in vascular grafts, a common issue affecting nearly 40% of grafts within 2 years of implantation. The...
- This $722,299 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a research initiative to use deep learning techniques to study normal variation in aortic valve hemodynamics and its link to the development of aortic stenosis. The primary objectives are to: 1) Measure aortic valve parameters in 100,000 UK Biobank participants using deep learning models, validate the measurements at UCSF, and develop models to identify...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
- This federal Project Grant award of $173,448, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research to quantify value- and equity-informed resource allocation thresholds for subpopulations living with hemophilia A. The research aims to create a public-facing, transparent, and independent microsimulation model to evaluate all existing prophylactic treatment strategies for persons living with hemophilia A. This will involve using a...
- This Project Grant award, titled "DEVELOPING IMPLEMENTATION SCIENCE EXPERTISE IN CARDIOVASCULAR HEALTH SERVICES RESEARCH", is funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $133,085 grant, awarded on September 1, 2025, supports research activities at the University of Michigan to improve the management of anticoagulant medication and increase the use of evidence-based outpatient treatment for low-risk...
This $410,956 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Michigan Technological University supports research to stratify thrombosis risk in Kawasaki disease patients using computational fluid dynamics (CFD) analysis of coronary artery aneurysms (CAA) and ectasia (CAE). The research aims to complement current clinical assessment based on the z-score metric with additional hemodynamic indices like flow velocity, wall shear stress, and residence time to better understand the risk of thrombosis formation in CAA and CAE. This 3-year project will leverage patient-specific CFD modeling to analyze flow patterns and develop improved risk stratification approaches beyond the current standard z-score. The findings could inform more targeted anticoagulation therapy for Kawasaki disease patients with coronary artery abnormalities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $411.0k | 8/18/25 |