Project Grant R15HL179671
- This federal Project Grant award, totaling $249,000.00, was provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Texas Southwestern Medical Center in Dallas, TX. The grant supports research to better understand the molecular determinants of atrial fibrillation (AF), a common and serious heart rhythm disorder. The research aims to investigate how the transcription factor TBX5 and the chromatin remodeling protein CHD4...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $673,598 to Baylor College of Medicine to conduct research on the role of cardiomyocyte-fibroblast signaling in atrial fibrillation (AF). The goal is to investigate how reduced production of the paracrine signaling molecule calcitonin, miR-31-dependent downregulation of the calcitonin receptor, and activated BMP1 signaling promote atrial remodeling, fibrosis, and AF...
- This federal Project Grant award for $769,761 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into the mechanisms by which obesity leads to atrial fibrillation. The awardee, Weill Medical College of Cornell University, is developing a mouse model of obesity-induced atrial fibrillation to investigate how nicotinamide adenine dinucleotide (NAD+) pathways and the ATF6 endoplasmic reticulum stress pathway...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA Program 93.837 Cardiovascular Diseases Research) provides $601,612 to Northwestern University to develop a novel epicardial high-definition device for detecting and terminating paroxysmal atrial fibrillation (AF). The 4-year project aims to create a fully implantable, organ-conformal system that can rapidly detect AF episodes and deliver painless, low-energy multi-pulse therapy to restore normal heart...
- This Project Grant award, valued at $242,250.00 and awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research to examine the relationship between atrial fibrillation, anticoagulation therapy, and retinal stroke. The research will utilize an instrumental variable approach to provide indirect evidence of the association between atrial fibrillation and retinal stroke, and how anticoagulation therapy may modify this relationship. The...
- This federal Project Grant award of $174,528, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to identify novel treatment targets for atrial myopathy, a condition that contributes to atrial fibrillation and associated heart failure, stroke, and mortality. The primary objective is to leverage human cohort data to discover circulating proteins and metabolites linked to both left atrial function and atrial myopathy, using...
- This Project Grant award of $231,000.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), to study the functional impact of atrial myosin mutations associated with familial atrial arrhythmia. The research aims to comprehensively analyze the effects of known genetic mutations in the a-cardiac myosin heavy chain, essential light chain, and regulatory light chain on myosin activity and sarcomere...
- This $540,771 Project Grant award from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) is for the project "Personalized Stroke Risk Stratification in Atrial Fibrillation: Integrating Probabilistic Graphical Models and High-Dimensional EHR Data for Interpretable Prognosis." The award supports research to develop a personalized, socially-aware risk stratification tool to improve stroke prevention among patients with atrial...
- This National Science Foundation (NSF) Engineering program (CFDA 47.041) project grant award of $650,000 supports research to advance the understanding of blood-clot interactions that may result in stroke for patients with heart rhythm disorders. Specifically, the award will enable the development of a computational model of the left atrium to investigate how the heart's structure changes blood flow patterns and elevates the risk of clot breakup, which can lead to stroke. The research will be...
- This federal Project Grant award of $598,636, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports the development of the EMULAATE platform by Spheric Bio Inc. The EMULAATE technology aims to address the mismatch between standard left atrial appendage occlusion (LAAO) devices and patient anatomy by enabling the assembly of personalized, soft implants directly inside the patient's body through a minimally-invasive procedure. This could...
The National Institutes of Health's National Heart, Lung, and Blood Institute awarded a $464,502 project grant to Tarleton State University under the Cardiovascular Diseases Research program (CFDA 93.837). The grant, awarded on September 1, 2025, will fund the development of an interactive computer model of the left atrium's electrophysiology to study the underlying mechanisms leading to atrial fibrillation. Key objectives include: 1) constructing an anatomically accurate 3D model of the left atrium using computed tomography angiography images, and 2) incorporating electrochemical and stochastic processes into the model to enhance the representation of Bachmann's Bundle. This research aims to generate a high-dimensional, nonlinear, dynamically evolving model capable of simulating the chaotic characteristics of atrial fibrillation, a leading contributor to strokes and heart failure.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $464.5k | 8/25/25 |