This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on dissecting the input-output relationships of developmental BMP signaling. The $104,838 award to Duke University will support research that aims to shed light on how cells perceive and respond to varying BMP signaling inputs, with the goal of uncovering fundamental principles of cell...
This Project Grant award, valued at $142,996.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research to investigate how migrating cells can influence the morphogenesis and directional growth of their extracellular matrix substrate, using the Drosophila caudal visceral mesoderm and trunk visceral mesoderm as a model system. The research aims to...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $495,204 to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to conduct research on the molecular basis for bone morphogenetic protein (BMP) receptor specialization and trafficking. The research aims to elucidate the specialized...
This federal Project Grant award of $329,834 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research at William Marsh Rice University to visualize and understand how extracellular morphogens, specifically the Nodal signaling pathway, shape embryonic development and cell fate patterning. The research will leverage CRISPR-edited human pluripotent stem cells to...
This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
This Project Grant award from the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation provides $390,593 to Syracuse University for research on the mechanoregulation of amnion patterning through activation of bone morphogenetic protein signaling. The 3-year project aims to study amnion development using a stem cell-derived human development model, with the goal of advancing knowledge in early human development and enabling the rational design of 3D stem...
This Project Grant award of $162,874 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program supports research on the regulation of protein dynamics in the ectoderm germ layer of Drosophila embryos. The award aims to measure proteome dynamics and post-transcriptional regulation during embryonic cell differentiation, using genetically modified morphogen-flattened Drosophila embryos. The research integrates deep...
This Project Grant award, valued at $427,625.00 and provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to redefine the cellular origins of the kidney's intermediate mesoderm. The award will fund novel lineage tracing of paraxial mesoderm and utilize whole embryo imaging to examine the development of paraxial, intermediate, and kidney cell populations....
The federal Project Grant award R01HD116750, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $760,617 to The Children's Hospital Corporation (Boston Children's Hospital) to conduct research on understanding the mechanisms of pluripotency transitions during peri-implantation development. The research aims to identify key transcription factors and elucidate the epigenetic...
This Project Grant award of $440,000 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research on the role of SMAD5 signaling in polycystic ovary syndrome (PCOS) at Baylor College of Medicine. The study aims to conduct a broad biochemical analysis to determine how a newly discovered SMAD variant alters canonical and non-canonical SMAD properties, and identify the causal...