Project Grant R15GM160989
- The University of California, Irvine (UCI) was awarded a $1,227,751 Project Grant from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) to develop "Chemical Glycobiology Tools to Decipher Host-Microbiota Interactions." The project aims to discover precise molecular, cellular, and spatial factors that allow commensal and probiotic microbes to modulate host immunity, with a focus on exo- and capsular polysaccharides as key modulators of innate...
- This federal Project Grant award of $277,380.00, provided by the Office of the Director at the U.S. Department of Health and Human Services under the Trans-NIH Research Support program (CFDA 93.310), supports the development of novel statistical methods for detecting microbiome-metabolome interactions. The research aims to create a powerful transfer-learning framework for high-dimensional regression models to uncover associations between gut microbes and their metabolites, which play a...
- This federal Project Grant award for $353,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the impact of xenobiotic exposure on the gut microbiome and its resilience against gastrointestinal pathogens. The research program aims to fill a critical knowledge gap by examining how xenobiotics and their biotransformation products affect the composition, metabolism,...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to define molecular mechanisms underlying the gut microbiome's ability to resist colonization by pathogens like Vibrio cholerae. The $2,065,745 grant, awarded to the Regents of the University of California at Riverside, aims to provide a mechanistic understanding of how the biochemical environment of...
- This National Science Foundation Project Grant award of $776,213 provides funding over five years from January 2023 through December 2027 for research and educational efforts focused on developing novel statistical methods to detect parallel evolution in microbiome metagenomic data. The grant is awarded under the Biological Sciences program (CFDA 47.074) to support basic biological research that strengthens the nation's scientific enterprise. Specifically, the University of California, Los...
- The Regents of the University of California received a five-year, $2.4 million Project Grant from the National Science Foundation to support the research project "MIM: A Thermodynamic Theory of Microbiome Assembly, Adaptation and Evolution Evaluated Using Modular Microbial Environments" from October 1, 2021 through September 30, 2026. This grant is being administered under the NSF's Biological Sciences program (CFDA 47.074), which aims to advance the fundamental biological sciences and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $557,900 Project Grant to the Massachusetts Institute of Technology (MIT) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds a long-term research strategy to study ongoing adaptation and selective forces within human microbiomes. Using a culture-dependent genomic approach, the project aims to characterize within-person evolution over a dozen microbial species found in the skin, vagina,...
- This federal Project Grant award of $914,479 from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund a research project led by The Trustees of Columbia University in the City of New York to study the spatial organization and stability of synthetic gut microbiome communities in gnotobiotic mice. The research aims to elucidate the principles governing the assembly and persistence of microbial communities in the human digestive tract, which are essential for human...
- This $835,564 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Utah to elucidate the mechanisms by which intestinal epithelial cells (IECs) interact with and regulate the gut microbiota to maintain intestinal homeostasis. Key objectives include investigating how IEC-derived...
- The University of California, Merced received a $550,108 Project Grant award under the National Institute of General Medical Sciences' (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to conduct fundamental research on the genetic regulation of microbial community formation, with a focus on biofilms. The project, which runs from May 5, 2025 to March 31, 2030, aims to provide new insights into the molecular and mechanistic bases of biofilm development, regulation, and...
The University Enterprises, Inc. (UEI) was awarded a $532,500.00 Project Grant by the U.S. Department of Health and Human Services National Institutes of Health under the Biomedical Research and Research Training program (CFDA 93.859). The project aims to examine the genetic determinants of gut microbiota function, with a focus on understanding the role of sorbitol metabolism in the commensal bacterium Paraclostridium bifermentans and its interactions with the pathogenic bacterium Clostridioides difficile. The research will elucidate the transcriptional regulation of sorbitol catabolic genes in P. bifermentans and how sorbitol utilization affects competition with C. difficile. Additionally, the project will establish an evolution model to highlight the intrinsic and environmental forces that shape P. bifermentans ecotype abundance. The award period runs from September 1, 2025, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $532.5k | 8/22/25 |