Project Grant R15GM159232
- This federal Project Grant award of $390,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the structural dynamics of G protein-coupled receptor (GPCR) oligomerization and its impact on cellular localization and signaling. The 5-year award, effective August 1, 2025, will fund investigations into the complexes formed between GPCRs, G proteins, β-arrestins, and GPCR kinases,...
- This federal Project Grant award of $329,976 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a multiscale modeling strategy to simulate ion selectivity in proteins. The principal investigator will utilize novel force fields to conduct molecular dynamics simulations that provide structural, dynamic, and thermodynamic insights into protein-ion interactions. The research aims to analyze the...
- This $406,250 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The project aims to develop novel computational methods that can accurately characterize the reorganization of water structure and its impact on the thermodynamics and kinetics of protein interactions. This will be applied to three specific projects: (1) interactions between reader proteins and...
- This Project Grant award, valued at $417,243 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the synthesis of homogeneous proteoglycan-like glycopeptide and glycoprotein libraries for microarray studies. The goal is to develop innovative chemical, chemoenzymatic, and chemoselective ligation strategies to produce well-defined proteoglycan structures, which will then be incorporated into...
- This $576,104 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the molecular mechanisms underlying transmembrane conduction and signaling in integral membrane proteins. The research aims to define the structural transitions and energy coupling processes that drive and regulate cyclical processes in membrane proteins, with a focus on understanding voltage...
- The Project Grant award in the amount of $778,444.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research aimed at understanding the structure and function of phospholipids and inositol phosphates in the cell nucleus. The research, conducted by a diverse group at Vanderbilt University Medical Center, focuses on investigating the structural biology and functional genomics of these...
- This $694,875 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Boston University Medical Campus to advance the understanding of G protein-coupled receptor (GPCR) and heterotrimeric G protein signaling plasticity. The research aims to define the physiological implications of non-GPCR activation of G proteins and develop innovative tools to measure G protein activity....
- This Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $437,709 award supports research to better understand the biophysical mechanisms underlying the generation of inward and outward curvature in cellular membranes. This research aims to elucidate the role of lipid bilayer interactions with the cytoskeleton and extracellular glycocalyx in controlling membrane bending...
- This federal Project Grant award, valued at $427,625.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the conformational dynamics and regulatory mechanisms of the KCNH family of ion channels. The research aims to examine the voltage sensor domain and S4 helix of KCNH channels to measure their structural changes during channel opening and closing. The project will...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $428,255.00 to Pennsylvania State University to investigate the structural and molecular mechanisms for the recognition of membrane geometry and the translation of membrane geometry into protein function. The key objectives of this 5-year research project, which runs from August 8, 2025 to July 31, 2030, are to...
This federal Project Grant award of $512,397, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to examine the structure of the intracellular domain (ICD) of glycine receptors in lipid bilayers. The research aims to use cross-linking mass spectrometry (CXMS) techniques to characterize the ICD structure in different allosteric states and investigate lipid-protein interactions. This work will complement existing high-resolution structural data for pentameric ligand-gated ion channels and provide new insights into the previously unresolved ICD structure. The award was granted to Duquesne University, a private research university in Pennsylvania, with a performance period from September 11, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $512.4k | 9/11/25 |