This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $278,848 to Brigham Young University to expand the capabilities and usage of the TELSAM protein crystallization chaperone. The funding supports research to develop experimentally validated guiding principles for the use of TELSAM, demonstrate its efficacy for a broad range of proteins, and showcase its applications and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of two digital applications to provide immediate feedback and assessment for student-folded protein models using 3D Molecular Designs' Mini-Toobers modeling tool. The $591,842 award will fund the creation of a Student Training App that uses augmented reality to give students real-time feedback on modeling alpha...
The National Institute of General Medical Sciences (NIGMS) awarded a $243,840 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The project, titled "An Effective Statistical Inference Framework to Develop Innovative Compensations for Protein Mutations," aims to develop quantitative methods for predicting the impact of protein mutations and identifying compensatory mutations that can restore normal protein...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,044,566 to Arizona State University (ASU) to develop machine learning models for studying protein interactions in the context of immune receptors. The key goals are: 1) creating effective embeddings of biological sequences to design protein language models, and 2) applying these embeddings to generate novel T-cell receptors (TCRs)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $202,274 to develop an easy-to-use computer program for predicting the structure and degrading efficiency of proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional molecules that induce the degradation of target proteins by recruiting them to E3 ubiquitin ligases. The awarded project aims to implement a...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $940,288 to Arizona State University (ASU) to develop an innovative platform for targeted protein degradation using DNA nanotechnology. The key objectives are to: 1) optimize a programmable DNA-based protein degradation system, 2) assess the impact of spatial factors on degradation efficiency, 3) integrate the DNA...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at the Albert Einstein College of Medicine to investigate protein motions associated with intrinsic disorder and their specific functions. The $584,420 award, with a performance period from April 1, 2025 to January 31, 2030, will fund spatiotemporal mapping and engineering studies of the "dark proteome" - areas of the...
This $294,147 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to advance modeling and simulation capabilities for characterizing macromolecular interactions within living cells. The key objectives are to: Characterize the intermolecular energy landscapes for different types of macromolecules through efficient all-atom simulation protocols integrated with docking methods. Develop new...
This Project Grant award of $350,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop an artificial intelligence-based platform for optimizing peptide-based drug candidates. The key products or services to be delivered include: Methods for encoding non-canonical amino acids and cyclic peptides to enable high-performance machine learning on commercial peptide sequence, activity, stability, and...
This $939,086 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support research to develop novel mass spectrometry-based approaches for profiling biomolecules, including proteins, lipids, and metabolites, at the single-cell level. The research aims to provide an unprecedented view of cellular regulation from genotype to phenotype by combining these mass spectrometry capabilities with...