This $504,175 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the role of non-coding RNA in regulating pluripotent stem cell biology and differentiation. The project, led by Yale University, leverages studies of adult pluripotent stem cells in planarians to investigate how piwi-interacting RNAs (piRNAs) and their binding partners, the piwi proteins, contribute to...
The National Institute of General Medical Sciences (NIGMS) awarded a $125,000 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to the Whitehead Institute for Biomedical Research. The grant, effective January 1, 2025 through December 31, 2026, supports research to comprehensively characterize how adult stem cell systems balance regenerative plasticity with the maintenance of distinct cell behaviors. Key research objectives include determining how...
This $462,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to establish the epigenetic mechanisms that govern embryonic stem cell (ESC) biology. The research aims to define how ESC gene expression programs and biology are regulated by DNA methylation and the TET family of DNA demethylases. Key objectives include: Dissecting the molecular and biological requirements...
The National Institute of General Medical Sciences (NIGMS) awarded a $790,774 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for The State University of New York, doing business as Stony Brook University. The grant, effective September 16, 2024 through July 31, 2029, supports research to deconstruct the molecular mechanisms underlying fast amoeboid cell migration, a poorly understood mode of three-dimensional cell movement....
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, provides $162,874 to The Trustees of Princeton University to conduct research on the regulation of protein dynamics in the ectoderm germ layer of Drosophila embryos. The key objectives are to: Quantify proteome differentiation and stochastic cell fate diversification using deep multiplexed proteomics and single-cell RNA sequencing (Aims...
This Project Grant award of $380,546 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on post-transcriptional regulation of stem and progenitor cell function, with a focus on spermatogonial stem and progenitor cells in the mouse model. The key objectives of the research are to: 1) Investigate how the RNA-binding protein and translational regulator DAZL enhances retinoic acid-mediated...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $224,088 to support research to determine the developmental origin and regulation of adult pluripotent stem cells in the regenerative animal Hofstenia. The key objectives are to: (1) identify the molecular pathway underlying adult pluripotent stem cell formation, (2) define the chromatin landscape enabling pluripotency, and (3)...
East Carolina University was awarded a $600,000 Project Grant from the National Science Foundation Division of Integrative Organismal Systems. The award is part of the Biological Sciences program (CFDA 47.074) and will fund research into regulatory mechanisms for cellular dedifferentiation in C. elegans germline from February 1, 2022 to January 31, 2025. The goal of the research is to advance understanding of major problems in biology by investigating how gene expression controls the process...
This Project Grant award for $479,487 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at The Johns Hopkins University to investigate how key physical cues, such as extracellular fluid viscosity, microenvironmental stiffness, and cellular confinement, regulate cell migration and function. The research aims to develop a comprehensive understanding of how these...
This Project Grant award of $389,600.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the physical mechanisms of 3D cell motility. The research aims to establish how distinct pools of actomyosin contractility are linked to the control of cytoplasmic hydraulic pressure to achieve 3D cell migration. Specific focus areas include understanding how the structure of the 3D extracellular...