Investigation of ssdna binding proteins and protein-ssdna interactions

Ended Project Grant Awarded Last action

Award ID
R15GM132846
Recipient
Awarding agency
Obligated
$1,193,928

Award facts

Assistance listing
93.859 Biomedical Research and Research Training
Completion date
Originally
Funding
  • $758,034.14 Federal
  • $435,894.00 Non-federal
Place of performance
North Carolina, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Molecular interactions between proteins and single-stranded DNA (ssdna) play crucial roles in many fundamental biological processes, such as DNA replication, DNA recombination, DNA repair, gene regulation, and genome stability. Ssdna-binding proteins encompass various degrees of binding specificity, ranging from highly specific to non-specific. Despite the critical roles of protein-ssdna interactions in essential biological processes, the investigation of protein-ssdna interactions lags far behind other types of protein-nucleic acids interactions, such as protein-double stranded DNA (dsdna) interaction. Currently there are no comprehensive, well-annotated resources for studying protein- ssdna interactions. This proposal aims to investigate the mechanism of protein-ssdna interactions by first constructing well-annotated protein-ssdna data resources and by performing comparative analysis at two different levels. The first is to compare structural features between protein-ssdna complexes with different binding specificity. The second is to investigate the similarity/differences between protein- ssdna and protein-dsdna complexes. In addition, we propose to predict novel ssdna binding proteins from the unannotated protein sequences by combining structure-based protein threading methods and sequence-based machine learning approaches.

Transactions

Action Federal Non-federal Date
Amendment -$113,754 $0
Amendment $0 $0
Amendment $435,894 $0
Original award $435,894 $435,894

Subawards

Subrecipient Amount Awarded
Toyota Technological Institute At Chicago Dr. Xu will co-supervise Dr. Guo's students to study machine learning algorithms for the prediction of ssDNA-binding proteins. Dr. Xu will also co-supervise Dr.… $89,049

Quick answers

Who received award R15GM132846?

R15GM132846 was awarded to University Of North Carolina At Charlotte by National Institute of General Medical Sciences (National Institutes of Health) on April 1, 2021.

How much is award R15GM132846 worth?

$1,193,928 has been obligated on R15GM132846: $758,034 in federal funding and $435,894 in non-federal funding.

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