Project Grant R15AI194161
- This $195,640 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a 5-year research program at Johns Hopkins University to study the vaginal microbiome and its contributions to bacterial vaginosis (BV). The research aims to evaluate mechanisms for treatment failure and identify subpopulations that may respond better to the antibiotic clindamycin versus the more commonly prescribed metronidazole....
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on elucidating the role of Akkermansia muciniphila in Group B Streptococcal (GBS) vaginal colonization and ascending infection. The $148,568 award will support research to investigate the specific mechanisms by which A. muciniphila promotes GBS interaction with human vaginal epithelial cells, potentially...
- This Project Grant award, valued at $126,460 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to identify ecological drivers of dysbiosis in the female reproductive tract. The research will use genetically tractable uropathogenic E. coli and specialized animal and tissue culture models to determine how host cell metabolism controls vaginal community composition and perpetuates...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $300,000 in funding to Topaz Biosciences, Inc. to discover and optimize novel endolysins that can selectively target Gardnerella vaginalis, the primary bacterial species associated with bacterial vaginosis (BV). The goal is to develop improved endolysins that are more active, thermostable, and pH tolerant than...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $404,273 to Virginia Commonwealth University (VCU) to conduct research on the effects of the bacteria Sneathia vaginalis on the amnion, which could play a role in preterm birth and premature rupture of membranes. The key goals of the project are to characterize the damage Sneathia vaginalis causes to the...
- This $1,025,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports the development of "MM-009", an intravaginal ring designed to continuously release lactic acid over a 30-day period. The goal is to treat and prevent bacterial vaginosis, a vaginal condition affecting millions of women in the U.S. The funding supports the IND-enabling development of...
- This federal Project Grant award of $243,750 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate how the bacterium Gardnerella promotes the pathogenesis of Neisseria gonorrhoeae, the causative agent of the sexually-transmitted infection gonorrhea. The key objectives are to determine the mechanisms by which Gardnerella virulence factors, including the cytolytic toxin...
- This $310,136 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) is funding the development of an intravaginal ring that can sustain high vaginal levels of lactic acid to treat and prevent bacterial vaginosis (BV). The funding supports research by Mucommune LLC, a biopharmaceutical company in Durham, North Carolina, to directly measure the rate of lactic acid loss from the vagina and then engineer a...
- The University of Rochester received a $462,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to study how the human microbiome regulates neutrophil responses in sepsis. The research aims to determine if differential priming of the immune system by healthy blood microbiomes predisposes patients to heterogeneous responses to sepsis. Preliminary evidence suggests that microbiome-mediated training of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $479,730 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin - Madison. The 5-year grant, effective from December 1, 2024 to November 30, 2029, will support research to elucidate the mechanisms by which prophages (viral DNA) in the gut symbiont Limosilactobacilus reuteri modulate the production of the antimicrobial compound reuterin. The research aims to...
The federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will provide $511,763 to Seattle University to conduct activity-based protein profiling of the vaginal microbiome. The goal is to understand how enzymes related to glycogen degradation and microbial proteases are associated with vaginal community composition and bacterial vaginosis. The 3-year project, starting September 1, 2025, will involve developing experimental systems and techniques to study molecular function in human cervicovaginal fluid samples. This research aims to inform the development of probiotic or drug-based therapies that can shift the vaginal microbiome to prevent or treat related health conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $511.8k | 8/27/25 |