This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $932,750.00 to Emory University to develop and utilize single cell techniques to gain unprecedented insight into West Nile Virus (WNV) infection of the lymphatics and spleen. The goal is to better define the cellular targets of WNV infection and understand how the antiviral immune response limits virus...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $4,319,570 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Washington. The grant funds research to investigate the innate immune response to West Nile virus (WNV) infection, a global flavivirus health concern. The key objectives are to: 1) Define the specific WNV pathogen-associated molecular patterns (PAMPs) that are recognized by the RIG-I-like receptors...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $369,431 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin-Eau Claire. The project aims to quantitatively describe the behaviors of schistosome miracidia, the aquatic stage that infects snail hosts, and identify the snail-secreted peptide that stimulates their accumulation. Researchers will generate high-resolution tracking data to extract behavioral...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $700,288 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of South Florida. The grant, titled "Phenotype-Based Screens to Identify Genetic Factors Associated with Gametocyte Development in Plasmodium falciparum," runs from November 2024 to October 2029. The project aims to use a functional genomics approach to identify P. falciparum genes essential for the...
The Virginia Commonwealth University was awarded a $746,009 Project Grant from the Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases. The grant falls under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research examining the cyclic-di-GMP signaling pathway and its role in the enzootic cycle of Lyme disease from November 18, 2022 through October 31, 2027. Specifically, the grant will fund...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,104,050 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis. The funding supports research to investigate the mechanisms by which the Plasmodium falciparum parasite impairs neutrophil function, thereby increasing susceptibility to invasive bacterial infections in malaria patients. Key objectives include identifying the molecular pathways by...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $530,385 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The grant, awarded on June 6, 2025, will support research to define how the host acetylation enzyme KAT5 regulates the enzymatic activities of the essential flavivirus protein NS3, which is critical for viral replication. Using molecular, biochemical, and...
The U.S. National Institute of Allergy and Infectious Diseases (NIAID) awarded a $4,874,388 Cooperative Agreement to Duke University under the Allergy and Infectious Diseases Research (CFDA 93.855) program. This 5-year award, running from June 2025 to May 2030, funds the establishment of a Center of Excellence (COE) for Multiscale Immune Systems Modeling. The COE aims to develop innovative solutions for multi-scale modeling of infectious and immune-mediated diseases, including HIV-1, SARS-CoV-2,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $213,000 Project Grant (R21AI185572) to the Morehouse School of Medicine (MSM) to support research on the "Role of ASIC1a Activation in ECM Associated Brain Injury and Mortality" related to cerebral malaria. The project will investigate the mechanisms by which the activation of the acid-sensing ion channel 1a (ASIC1a) contributes to brain injury and mortality in cerebral malaria, a potentially lethal...
This $790,000 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to advance the understanding of immune responses and neuroinvasive disease mechanisms related to West Nile virus infections. Key objectives include: Defining the cells and signaling pathways that initiate the immune response to West Nile virus and control viral neuroinvasion. Elucidating the signaling...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $873,362 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to East Carolina University (ECU) on August 2, 2024. The grant will fund a 3-year study to assess the acute and long-term physical, social, and cognitive impacts of La Crosse encephalitis (LACE) in western North Carolina. Specifically, the project aims to: 1) evaluate the impacts of LACE on cases and their families through interviews and assessments, 2) determine the direct and indirect economic costs of LACE, and 3) assess environmental risk factors for LACE transmission at case residences to inform risk reduction interventions. Western Carolina University will serve as a sub-awardee, supporting field activities, data management, and manuscript development for the project.