Project Grant R15AG101508
- The National Institute on Aging awarded the University of Texas Medical Branch at Galveston $1.788 million on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the interplay between microglia and tau oligomer polymorphs in cognitive resilience among individuals with Alzheimer's disease neuropathology who remain cognitively intact. The project tests the hypothesis that brain-derived tau oligomers isolated from cognitively resilient individuals exhibit reduced toxicity...
- The National Institute on Aging awarded Rutgers, The State University $225,256 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of big tau protein in preventing tau pathology in Alzheimer's disease. The research examines why selective brain regions such as the cortex and hippocampus develop tau pathology in Alzheimer's disease while the cerebellum and brainstem largely remain intact. The investigator has identified big tau, a tau isoform with a...
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- The National Institute on Aging awarded $654,506 to The Regents of The University of Colorado, doing business as University of Colorado-Denver, on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research into glial-associated immune dysregulation in Alzheimer's disease pathology, specifically investigating how reactive astrocytes drive immune dysfunction, alter dendritic structure in the brain, and contribute to synaptic dysfunction and cognitive decline. The...
- This federal Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $443,365.00 to the University of Maryland, College Park to conduct research on the brain renin-angiotensin system and its relationship to Alzheimer's disease. The research, which runs from August 1, 2024 to July 31, 2026, will focus on: Measuring brain angiotensin peptides and peptidases in a genetically diverse Alzheimer's disease mouse model to understand the...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of Missouri System $676,608 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of the gut-brain axis in Alzheimer's disease mitigation through a translational study combining human and preclinical animal experiments. The project examines how dysbiosis—microbial imbalance—correlates with Alzheimer's disease biomarkers (amyloid plaques, tau...
- The National Institute on Aging awarded the University of Texas Southwestern Medical Center $441,126 on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate STING regulation of tau seeding and tauopathy in Alzheimer's disease. The research will determine the molecular mechanism by which STING activation promotes tau seeding in cells and will use genetic approaches to establish the role of distinct STING functions in mouse tauopathy models. The work addresses how...
- The National Institute on Aging awarded The Johns Hopkins University $653,100 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate poly(ADP-ribose) polymerase 1 (PARP1) and macrophage migration inhibitory factor (MIF) nuclease activity in tau-related neurodegeneration and cognitive dysfunction. The research will examine neurobehavior and neuropathology in PS19 transgenic mice models with PARP1 knockout and MIF nuclease-deficient or tautomerase-deficient genetic...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded Vanderbilt University $421,250 on July 1, 2026, through the Aging Research program (CFDA 93.866) to develop a programmable RNA-based sensing circuit that targets inflammatory reactive astrocytes in Alzheimer's disease. The project engineers a single, compact RNA vector that harnesses endogenous ADAR enzymes to selectively modulate disease-driving astrocytes based on their transcriptional state. The system produces therapeutic payloads, such as...
The National Institute on Aging awarded Towson University $471,303 under the Aging Research program (CFDA 93.866) on August 15, 2026, to define the role of varicose projection astrocytes in Alzheimer's disease pathology. The project investigates varicose projection (VP) astrocytes, a novel reactive astrocyte phenotype associated with neuroinflammatory conditions including Alzheimer's disease. Using human-induced pluripotent stem cell (hiPSC)-based models and human postmortem brain tissue, the research will characterize the molecular signature of VP astrocytes through patch-seq transcriptomic profiling and assess their functional impact on neuronal degeneration via hiPSC-derived neuron-astrocyte co-cultures. The project tests cytokine withdrawal and pharmacological inhibition of inflammatory pathways to explore whether the VP astrocyte phenotype presents a targetable cellular response in disease. Undergraduate researchers at Towson University will participate through a course-based undergraduate research experience (CURE) integrated within the laboratory work. The award runs through July 31, 2029, with performance at Towson, Maryland. Towson University is a component of the University System of Maryland.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $471.3k | 8/14/26 |