The University of Iowa received a $173,175 federal Project Grant award on August 1, 2024 from the National Center for Advancing Translational Sciences (NCATS), Catalog of Federal Domestic Assistance (CFDA) Program 93.350. The grant supports research to understand the biological effects of ATP-binding cassette A3 (ABCA3) gene mutations in human alveolar type 2 epithelial cells and develop a gene therapy strategy to express ABCA3 and potentially reverse the disease course in severe cases of ABCA3 deficiency. The university is collaborating with Boston University's Chobanian & Avedisian School of Medicine, which received a sub-award to perform experiments related to directed differentiation of human induced pluripotent stem cells into alveolar epithelial type 2 cells and lentiviral vector transduction to transfer the ABCA3 coding sequence.
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