Project Grant R03TR004580
Award Date
8/15/23
Completion Date
7/31/24
Dollars Obligated
$156K
Federal Agency
National Center for Advancing Translational Sciences
Federal Grant Program
93.350
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
Similar Awards
This $1,694,306 Project Grant award, funded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research to investigate the role of smooth muscle alpha-actin (SMA) in the development of Moyamoya disease (MMD). The key research objectives are: Using a mouse model, assessing cell fate trajectories of wild-type and mutant SMCs over developmental time to understand how ACTA2 p.R179C variants disrupt SMC differentiation. Correcting the ACTA2...
This federal Project Grant award of $128,877, provided by the National Heart Lung and Blood Institute under CFDA 93.837 Cardiovascular Diseases Research, supports research to elucidate the mechanisms necessary for curing myelodysplastic syndromes (MDS). The key objectives are to: (1) assess the potential for detecting MDS hematopoietic stem cells to predict relapse after allogeneic stem cell transplant, and (2) investigate the molecular and clonal evolution of MDS stem cells that enables their...
This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...
The University of Texas at San Antonio (UTSA) was awarded a $412,500 Project Grant (R21NS135514) under the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research using human cortical organoid models to uncover the cellular and molecular mechanisms by which mutations in the CHD2 gene contribute to developmental and epileptic encephalopathy, a severe form of...
This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (CFDA 93.350 National Center for Advancing Translational Sciences), will provide $155,559 to the University of Delaware to investigate the impact of the histone methyltransferase SETDB1 on mitochondria. The research aims to define how SETDB1 affects mitochondrial morphology, function, and protein abundance using advanced imaging techniques and quantitative...
This Project Grant award of $1,245,515.38 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at The Methodist Hospital Research Institute (HMRI) to study the relationship between cell metabolism and epigenetic regulation in transdifferentiation and vascular regeneration. The key objectives are to: Determine the molecular metabolic pathway that leads to the transdifferentiation of fibroblasts into endothelial cells, which can...
The University of Kentucky Research Foundation was awarded a $153,000 Project Grant from the National Center for Advancing Translational Sciences (NCATS) with a grant ID of R03TR004310. The project aims to investigate the effects of vitamin D deficiency on the pathological progression of chronic cerebral hypoperfusion using animal models of vascular dementia and moyamoya syndrome. Key objectives include quantifying the impacts on hypoxia-induced angiogenesis, vascular pathology, and inflammatory...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) totals $408,750 and is effective from September 15, 2024 through July 31, 2029. The award will support the development of large-scale composite hypothesis testing approaches for performing translational genetics analyses. Specifically, the research will focus on creating interpretable and robust statistical methods for...
This Project Grant award, with a total funding amount of $265,752, was made by the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), under CFDA Program 93.350. The grant supports a predoctoral training program at the University of Texas Health Science Center at Houston (UTHealth) that aims to develop future leaders in translational science research. Specifically, the program will train six predoctoral fellows to build a...
This $974,000 five-year Project Grant award (Federal Grant Program ID 93.350 - National Center for Advancing Translational Sciences) from the National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) supports the University of Texas Health Science Center at Houston's (UTHealth) CTSA K12 Program. The program aims to develop a well-trained and highly adaptable clinical and translational science workforce capable of rapid design and deployment of clinical trials...