This $202,728 federal Project Grant awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program funds a collaborative research project to develop a theragnostic (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project aims to integrate data science, synthetic biology, and additive manufacturing to model the complex interplay of host, microbial, and environmental factors in IBD, and develop an engineered...
This National Science Foundation (NSF) Project Grant, awarded under the Computer and Information Science and Engineering (CISE) program (CFDA 47.070), provides $168,690 to the Florida Institute of Technology Inc. (Florida TECH) to develop a theragnostic (therapeutic + diagnostic) system for inflammatory bowel diseases (IBD). The project aims to model the complex interplay of host, microbial, and environmental factors that trigger IBD using data science, and then leverage synthetic biology and...
This $149,403 federal Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) to North Carolina Agricultural and Technical State University (NC A&T) aims to develop a "theragnostic" (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project integrates data science, synthetic biology, and additive manufacturing to: 1) model the complex interactions between host, microbial, and environmental factors underlying...
This Project Grant award of $790,359.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The award will fund the design, characterization, and optimization of a bioengineered Saccharomyces boulardii yeast that can secrete nanobody...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $1,007,304 supports research to investigate how genetic variants associated with inflammatory bowel diseases (IBD) affect the function of pathogenic T helper 17 (Th17) cells. The research aims to: Use massively parallel reporter assays (MPRAs) to identify putatively causal IBD variants within the accessible...
This federal Project Grant award of $151,643, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on developing and evaluating Proteolysis Targeting Chimeras (PROTACs) to stabilize hypoxia-inducible factors (HIFs) as a potential therapeutic approach for inflammatory bowel disease (IBD). The principal investigator, Dr. Ornelas Sanchez, and his...
This Project Grant award of $2,175,283.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to reprogram intestinal immunity and prevent/cure necrotizing enterocolitis (NEC) in preterm neonates. The research, led by the University of North Carolina at Chapel Hill, will utilize a large NEC biorepository with samples from thousands of premature infants to...
This Project Grant award, totaling $184,572 and provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, aims to characterize the transmural nature of ulcerative colitis (UC) and its associated disease-related outcomes using intestinal ultrasound. The research will test the hypothesis that transmural structural alterations to the bowel wall in UC lead to poor clinical outcomes compared...
The National Center for Complementary and Integrative Health (NCCIH) awarded a $157,409 Project Grant under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to Seattle Children's Hospital to develop a mobile "just-in-time" adaptive intervention (JITAI) for young adults with chronic pain. The key objectives are to: 1) conduct an ecological momentary assessment study to identify contextual factors that predict pain exacerbations in young adults to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $1,739,177 to The Leland Stanford Junior University to conduct research on the role of impaired cellular RNA editing in the etiology of inflammatory bowel disease (IBD). The research aims to: Leverage genetic data to prioritize double-stranded RNA (dsRNA) loci associated with IBD susceptibility and systematically assess how risk and protective alleles affect dsRNA editing....