The University of North Carolina at Chapel Hill (UNC-CH) was awarded a $233,249 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) by the National Institutes of Health (NIH) Office of the Director. The award, effective September 20, 2024 through June 30, 2028, supports the development of two novel tools: 1) a virus purification pipeline that can achieve less than 1 genome copy per milliliter sensitivity using larger sample volumes, and 2) a single virion detection...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $767,077 to the University of North Carolina at Chapel Hill (UNC-CH) to validate and extend a platform technology for the delivery of protein-based drugs, with a specific focus on thrombolytic enzymes. The proposed research seeks to accommodate various thrombolytic proteins, investigate...
This federal Project Grant award of $1,535,020.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support research at the University of North Carolina at Chapel Hill focused on understanding how alternative splicing, an RNA processing mechanism, influences key cellular processes such as cytoskeleton dynamics, local translation, and transcription regulation. The project will...
This federal Project Grant award in the amount of $381,995 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds research to investigate the impact of low oxygen environments on the cellular uptake and efficacy of messenger RNA (mRNA) lipid nanoparticles (LNPs) - an emerging technology for investigating and manipulating cells. The research will focus on two key areas: 1) comparative...
The University of North Carolina at Chapel Hill (UNC-CH) received a $1,377,516 Project Grant from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to conduct cell-type-specific proteomic research on brain white matter. The 3-year project aims to define the molecular landscape of brain white matter with regional, temporal, cellular, and subcellular specificity, in both healthy mice and disease models. Researchers will leverage proximity-based...
This $233,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to develop a novel platform for gene therapy targeting the human microbiome. The University of North Carolina at Chapel Hill will work to engineer self-recirculating, non-replicating bacteriophages as vectors for precise genetic modifications of specific commensal bacteria within complex microbial...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,166,250.00 to the University of North Carolina at Chapel Hill to conduct research on understanding how evolutionary processes shape patterns of genetic variation in compact genomes. The research aims to develop new computational, statistical, and theoretical methods to jointly model the effects of selection, recombination,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $242,310 to Trustees of Boston University to establish a systematic workflow for functionally reconstituting human G protein-coupled receptors (GPCRs) in yeast, and conduct directed evolution campaigns to discover nanobody ligands for orphan GPCRs. The award aims to deorphanize many orphan GPCRs, enabling exploration of new GPCR biology...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $300,892 to the University of North Carolina at Chapel Hill (UNC-CH) to identify and characterize dehydrated nonribosomal peptides derived from Streptomyces bacteria. The research aims to elucidate the biosynthetic pathways and biological roles of these antimicrobial natural products, which could lead to the development of new...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $147,656 to the University of North Carolina at Chapel Hill (UNC-CH) to develop a modular system of chimeric tRNA synthetases. The goal is to enable more flexible incorporation of non-canonical amino acids into macrocyclic peptide therapeutics, which can target "undruggable" proteins. The project will involve engineering...