Project Grant R03HL185269
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $651,829 Project Grant to Boston University Medical Campus on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research examining postpartum hypertension as a pathway to prevent recurrent hypertensive disorders of pregnancy (HDP). The project leverages Boston Medical Center's safety-net hospital setting, where approximately 30% of obstetric patients...
- Federal Project Grant Award Summary Yale University received a $806,978 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of June 30, 2030. The award funds research investigating Plasminogen Activator Inhibitor 1 (PAI-1) as a therapeutic target for maternal endothelial dysfunction in preeclampsia. The research aims to develop novel therapeutic strategies...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Pittsburgh a Project Grant totaling $190,168 under the Cardiovascular Diseases Research program (CFDA 93.837) on July 2, 2026, with completion targeted for April 30, 2031. This award supports Dr. Malamo Countouris' research program investigating strategies to reverse left ventricular remodeling in women with a history of preeclampsia who subsequently develop hypertension. The research...
- Federal Grant Award Summary Brigham and Women's Hospital received an award of $855,585 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), with an award date of August 20, 2025, and a completion date of July 31, 2028. This Project Grant funds the development and adaptation of an antihypertensive self-titration intervention for routine implementation in U.S. primary care settings. The project addresses the clinical challenge...
- Federal Project Grant Award Summary Brigham and Women's Hospital received a $1,540,621 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for June 30, 2030. The award funds basic science research into the molecular mechanisms driving early-stage pulmonary arterial hypertension (PAH), with particular focus on endothelial inflammation, C-terminal SRC kinase...
- Federal Project Grant Award Summary Women & Infants Hospital of Rhode Island received a $875,534 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), with an award date of July 6, 2026 and ultimate completion date of March 31, 2031. The research project, titled "A Hidden Phenotype: Understanding Subclinical Deficits in Attention, Executive Function, and Social Communication in Children Born...
- Federal Project Grant Award Summary Kaiser Foundation Hospitals' Kaiser Foundation Research Institute received a $751,124 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) awarded on September 15, 2025, with completion targeted for June 30, 2030. The grant funds research investigating optimal physical activity (PA) timing, intensity, and 24-hour activity composition for the prevention of hypertensive...
- Federal Project Grant Summary The University of Kansas Medical Center Research Institute, Inc. received a $556,103 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 15, 2026, with completion targeted for March 31, 2030. The research initiative investigates the role of ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) in the pathogenesis of...
- Federal Project Grant Award Summary Brigham & Women's Hospital Inc. received a $171,858 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with an ultimate completion date of July 31, 2030. The award funds a research initiative titled "Computed Tomography for Early Detection and Phenotyping of Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease...
- Federal Grant Award Summary Rhode Island Hospital, a division of Lifespan Corporation and Brown University affiliate, received a $391,392 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective September 8, 2025. The award supports development and feasibility testing of the Active, Nourished, and Empowered Teens (ANET) program, a modular nutrition and physical activity intervention designed to address...
Women & Infants Hospital of Rhode Island received a $244,569 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective July 15, 2026, with completion expected June 30, 2028. The grant funds a single-site randomized controlled trial (RCT) designed to pilot test the feasibility of conducting a postpartum clinical trial evaluating enalapril versus standard-of-care treatment in women with a history of preeclampsia. The research will leverage the institution's remote blood pressure management program to enroll participants and collect clinical data. The primary deliverables include: (1) demonstration of trial feasibility metrics for conducting a larger NIH-funded RCT of postpartum enalapril therapy; and (2) preliminary evidence regarding enalapril's effects on blood pressure control and cardiac remodeling at four months postpartum in the study population. This R03 mechanism represents a proof-of-concept phase designed to generate foundational data and methodological insights that will support a future, larger-scale RCT. The research addresses a critical clinical gap, as current postpartum management of preeclampsia-related cardiovascular disease risk focuses primarily on blood pressure control, whereas enalapril—an angiotensin-converting enzyme inhibitor—offers potential cardioprotective benefits through anti-inflammatory and anti-fibrosis mechanisms.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $244.6k | 7/15/26 |