Project Grant K23HL179475
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Pittsburgh a Project Grant of $701,449 under the Cardiovascular Diseases Research program (CFDA 93.837) effective June 1, 2026, through April 30, 2031. This award funds mechanistic research investigating the role of peroxisome proliferator-activated receptor alpha (PPARALPHA) activation in sex-based differences in doxorubicin-induced cardiotoxicity. The research delivers three primary...
- Federal Grant Award Summary The University of Pittsburgh received a $109,076 Project Grant award from the National Heart, Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 10, 2025, with completion targeted for September 9, 2029. Based on the award documentation and program parameters, this funding supports hypothesis-driven research in cardiovascular science, consistent with NHLBI's mission to advance prevention and...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $651,829 Project Grant to Boston University Medical Campus on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research examining postpartum hypertension as a pathway to prevent recurrent hypertensive disorders of pregnancy (HDP). The project leverages Boston Medical Center's safety-net hospital setting, where approximately 30% of obstetric patients...
- Federal Project Grant Summary The University of Pittsburgh received a $1,420,780 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025, with completion targeted for May 31, 2029. The grant funds basic and translational research to elucidate the mechanistic requirements of ALK1 (Activin Receptor-Like Kinase 1) ligands—specifically bone morphogenetic proteins 9 and 10 (BMP9 and...
- Federal Project Grant Award Summary The University of Pittsburgh received a $756,607 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026, with completion targeted for April 30, 2033. This award funds basic and translational research investigating the therapeutic potential of enhancing macrophage lysosomal degradative capacity as a novel intervention strategy for atherosclerosis and...
- Federal Grant Award Summary The University of Pittsburgh received $782,341 in funding from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) for a Project Grant awarded July 15, 2026, with completion targeted for May 31, 2031. The project will develop and validate an adaptive, artificial intelligence-guided, closed-loop neuromodulation system designed to predict and prevent ventricular arrhythmias (VAs)—including ventricular...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Vanderbilt University Medical Center a $154,142 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) effective July 1, 2026, through June 30, 2031, to conduct a research study examining preeclampsia recurrence patterns and risk factors. The grant supports a research and training initiative led by Dr. Sundermann to identify drivers of preeclampsia recurrence with the ultimate...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $616,864 Project Grant on September 3, 2025, to the University of Pittsburgh to conduct a mixed-methods research study examining sleep-based strategies as an enhancement to diet, physical activity, and self-regulation interventions for optimizing maternal health and reducing cardiovascular disease (CVD) risk during the perinatal period. The research leverages existing trial data from the Health...
- Federal Project Grant Summary The University of Pittsburgh received $767,953 in funding from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) for a project titled "Structural Biomimicry to Improve Engineered Heart Valve Leaflet Function and Remodeling." The award was obligated on July 1, 2026, with an ultimate completion date of March 31, 2030. This project addresses critical gaps in tissue-engineered heart valve...
- Federal Project Grant Award Summary The University of Pittsburgh received a $190,188 Project Grant award dated April 10, 2026, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports a five-year research initiative through March 31, 2031, investigating biomarkers and predictors of treatment response in chronic anemia associated with sickle cell disease (SCD). The research will evaluate how...
Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Pittsburgh a Project Grant totaling $190,168 under the Cardiovascular Diseases Research program (CFDA 93.837) on July 2, 2026, with completion targeted for April 30, 2031. This award supports Dr. Malamo Countouris' research program investigating strategies to reverse left ventricular remodeling in women with a history of preeclampsia who subsequently develop hypertension. The research delivers critical training and clinical trial execution products, including a randomized controlled trial examining pharmacologic interventions to mitigate cardiovascular disease risk in this high-risk patient population. Dr. Countouris will be mentored by leading experts in pharmacologic clinical trials, adverse pregnancy outcomes, and cardiovascular imaging to build competencies in trial design, conduct, molecular pathways of myocardial remodeling, and research team leadership. The award addresses a significant gap in cardio-obstetric medicine by developing evidence-based prevention therapies for women experiencing the long-term cardiovascular consequences of preeclampsia. Preliminary data demonstrate that women combining preeclampsia history with current hypertension exhibit the highest rates of left ventricular remodeling within a decade of delivery, along with associated coronary microvascular dysfunction. The research outputs will generate knowledge to support clinical decision-making and establish Dr. Countouris as an independent physician-scientist capable of leading future multicenter cardiovascular trials within the emerging cardio-obstetrics field.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $190.2k | 7/14/26 |