Metabolic syndrome severity in all of US: relationship with social determinants of health and with long-term risk for cardiovascular disease

Ended Project Grant Awarded Last action

Award ID
R03HL172130
Recipient
Awarding agency
Obligated
$351,492

Award facts

Completion date
Originally
Funding agency
Office of the Director National Institutes of Health, Department of Health and Human Services
Place of performance
Virginia, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
In this project we aim to validate tools that researchers (including other all of US researchers) can utilize to assess and follow the severity of metabolic syndrome (mets) among study participants, and we will also evaluate characteristics of mets among minoritized groups for use in personalized medicine in clinical practice. Mets is a cluster of cardiovascular disease (CVD) risk factors that occur together more frequently than would be expected by chance, as though they are driven by a common underlying process that is related to risk for future type 2 diabetes (T2D) and CVD. We previously formulated mets severity z-scores (mets-z) specific to SEX and to three different race/ethnicities (individuals who are non-hispanic white, non-hispanic black or hispanic), but we did not previously have statistical power to assess for-and if necessary derive- unique mets-z scores for other racial/ethnic and sexual/gender groups. In particular asian american individuals have been noted to manifest insulin resistance at a lower BMI (suggesting unique manifestation of mets), and many sexual/gender sub-groups have been noted to have high levels of chronic stress from discrimination, which could also affect mets severity. We propose to use confirmatory factor analysis to assess mets severity among multiple minoritized race/ethnicity and sexual/gender groups in all of US. If the loading factors for the individual mets components differ for a specific population sub-group, we will derive a unique mets severity z-score for that group (e.g. among individuals who are asian american); if the mets loading factors are similar to other groups, we will utilize the corresponding mets-z score for that group's set of loading factors. We will then assess how these mets-z scores relate to social determinants of health (sdoh), including perceived discrimination and depressive symptoms- the physiological stress from which can exacerbate mets. This may help in highlighting the importance of assessing and considering sdoh in clinical care. Finally, we will evaluate how baseline mets-z is related to longitudinal risk for T2D and CVD, including assessing for whether this differs by racial/ethnic and sexual gender sub-groups. Our overall goal is to provide support for personalized medicine considerations for all individuals, including minoritized groups. These data will help validate specific mets-z scores that can be used to assess relationships with metabolic health for other topics of interest to multiple investigator teams in all of US.

Transactions

Action Obligated Date
Amendment $0
Amendment $14,994
Amendment $168,249
Amendment $168,249
Amendment -$168,249
Amendment -$168,249
Amendment $168,249
Original award $168,249

Quick answers

Who received award R03HL172130?

R03HL172130 was awarded to Rector & Visitors Of The University Of Virginia by National Heart Lung and Blood Institute (National Institutes of Health) on September 10, 2023.

How much is award R03HL172130 worth?

$351,492 has been obligated on R03HL172130.

Which agency awarded R03HL172130?

National Heart Lung and Blood Institute (National Institutes of Health) awarded R03HL172130, with funding from Office of the Director (National Institutes of Health).

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