Project Grant R03ES037055
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded the University of Hawaii at Manoa a $156,500 Project Grant (CFDA 93.865, Child Health and Human Development Extramural Research) on September 26, 2025, with a completion date of August 31, 2027. The project develops and applies pluripotent stem cell-based new approach methodologies (NAMs) to evaluate the teratogenicity and reproductive safety risks of memory-enhancing dietary...
- Federal Project Grant Award Summary The University of Hawaii at Manoa received a $194,292 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through June 30, 2028. This research project investigates bacterial dispersal and nutrient transport mechanisms along fungal hyphae, with applications to understanding bacterial behavior in complex environments including built...
- Federal Grant Award Summary Bioprinting Laboratories Inc. received a $306,872 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded July 8, 2025, with completion targeted for October 31, 2026. The company is developing a high-throughput screening platform for assessing developmental neurotoxicity (DNT) in commercially used chemicals. The primary deliverable is an engineered system combining genetically...
- This $156,500 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to establish an in vitro model of the human yolk sac using human pluripotent stem cells. The University of Hawaii is the primary awardee and will characterize the stem cell-derived yolk sac organoid to assess its functional similarities to the human yolk sac. They will also examine the effects of high glucose levels on the...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded Johns Hopkins University a $155,000 Project Grant on August 22, 2025, through the Environmental Health program (CFDA 93.113) to support research infrastructure and tool development for the Caenorhabditis Natural Diversity Resource (CaeDR). The grant funds Dr. Michael Sauria, a Research Software Engineer (RSE) in the Andersen Lab, to oversee critical computational and technical improvements to...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of North Carolina at Chapel Hill a $249,000 Project Grant effective September 12, 2025, through August 31, 2028, under the Environmental Health program (CFDA 93.113). This research initiative investigates the associations between prenatal exposure to phthalates and phthalate alternatives—ubiquitous endocrine-disrupting chemicals—and cardiometabolic development in fetuses and...
- Federal Project Grant Award Summary Purdue University received a $162,795 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective July 10, 2025, through June 30, 2030. The award supports the development and delivery of an innovative Toxicology Training Program designed to prepare PhD graduate students in bidirectional translational research across multiple biological scales. The program utilizes...
- Federal Grant Award Summary The Mentoring and Skills Development Training Program in One Environmental Health Toxicology (MSDT-OEHT) is a $542,954 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, Davis, effective August 15, 2025, through April 30, 2030. This national mentoring and skills development training initiative addresses a critical workforce gap in...
- Federal Grant Award Summary The University of Hawaii at Manoa received a $132,102 Project Grant award from the National Oceanic and Atmospheric Administration (NOAA) under the Marine Mammal Data Program (CFDA 11.439), effective October 1, 2025, through September 30, 2026. This Priority 1B proposal, submitted to the John H. Prescott Marine Mammal Rescue Assistance Grant Program, supports enhanced capacity for conducting necropsies and improving detection of illness or injury in stranded marine...
- Federal Project Grant Summary Midwestern University received a $521,992 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 1, 2025, with completion targeted for August 31, 2028. This award funds research investigating how phthalate exposure during critical developmental windows disrupts spermatogenesis through disruption of Liver Receptor Homolog-1 (LRH1) signaling in Sertoli cells. The...
The University of Hawaii at Manoa received a $156,500 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective April 9, 2026, through April 8, 2028. The award funds the development and validation of New Approach Methodologies (NAMs) for developmental and reproductive toxicity (DART) assessment using morphogenesis models derived from pluripotent stem cells. The project leverages previously developed mouse and human stem cell morphogenesis models that recapitulate key morphological and molecular events of early embryogenesis in vitro to establish validated screening tools that can serve as alternatives to traditional animal testing in pharmaceutical drug development. The deliverables under this award include rigorous validation of the stem cell-based morphogenesis models according to International Council for Harmonisation (ICH) guidelines using reference drugs with comprehensive in vivo toxicokinetics data. By establishing validated NAMs for DART assessment, this research supports the FDA Modernization Act 2.0 objectives to enable adoption of non-animal alternative tests for regulatory approval and safety assessments. The project aims to develop first-tier screening tools that can identify potentially toxic drugs before proceeding to animal testing, thereby reducing live animal use while maintaining scientific rigor and regulatory acceptance standards in pharmaceutical development.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $156.5k | 4/9/26 |