Project Grant R03DK147504
- Federal Grant Award Summary The Beckman Research Institute of the City of Hope received a $178,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective May 1, 2026, through April 30, 2028. The award funds research investigating how the native pancreatic microenvironment regulates human islet cell function in health and Type 1 Diabetes (T1D). The...
- Federal Grant Award Summary The Beckman Research Institute of the City of Hope received a $153,554 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, with a completion date of July 31, 2030. The award funds research on alpha cell heterogeneity and its implications for Type 1 Diabetes (T1D) therapy development. The principal...
- Federal Project Grant Award Summary The Beckman Research Institute of the City of Hope received $868,670 in funding from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for research on beta cell regeneration therapy in Type 1 Diabetes (T1D). The award, effective February 15, 2026, and concluding December 31, 2030, funds preclinical research exploring combination therapeutic...
- Summary of Federal Project Grant Award The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Beckman Research Institute of the City of Hope $1,264,088 on July 21, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund research on epigenetic regulation of genomic stability in beta-cell homeostasis. The project, which extends through April 30, 2030, addresses critical gaps in understanding how pancreatic beta...
- Federal Grant Award Summary The Beckman Research Institute of the City of Hope received a $2.16 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for the period May 1, 2026, through April 30, 2029. The research project, titled "Circulating Extracellular Vesicles as a Marker of Human Type 1 Diabetes Pathogenesis," will investigate circulating...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1.45 million Project Grant to Beckman Research Institute of the City of Hope, effective August 20, 2025, through June 30, 2030, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This award funds fundamental and translational research investigating chromatin remodeling factors and mechanisms in diabetic microvascular complications. The...
- Grant Award Summary The Beckman Research Institute of the City of Hope received a $847,746 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for the five-year period commencing September 1, 2025 through August 31, 2030. The research project, titled "Role of UPR Transducer XBP1 in Pancreatic Beta Cell Survival and Function Under Metabolic Stress,"...
- Federal Grant Award Summary The Beckman Research Institute of the City of Hope received a $140,116 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, with a completion date of July 31, 2028. The award supports fundamental research investigating the mechanisms of intestine-white adipose tissue (WAT) crosstalk in metabolic...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Scripps Research Institute a $801,662 Project Grant effective August 15, 2025, through June 30, 2029, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research project investigates the initiation of anti-islet autoimmunity in Type 1 Diabetes (T1D), a CD4 T cell-mediated autoimmune disease, with particular focus on understanding the role...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a Project Grant of $248,975.00 to The Regents of the University of Colorado-Denver under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for research activities spanning from May 15, 2026, through April 30, 2029. The funded research investigates pancreatic beta-cell glucose toxicity and its relationship to messenger RNA (mRNA) translation, with...
The Beckman Research Institute of the City of Hope received a $178,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective May 1, 2026 through April 30, 2028. This award supports fundamental and translational research focused on understanding stress response pathways in Type 1 Diabetes (T1D) through three-dimensional spatial and translational profiling methodologies. The funded research aims to characterize how proinflammatory cytokines modulate pancreatic beta cell messenger RNA (mRNA) translation and neoantigen production during T1D progression. Specifically, the project will define how cytokine signaling selectively modulates beta cell stress pathways, map non-canonical RNA translation mechanisms including upstream open reading frames (uORFs) and frameshift translation, and identify how chronic integrated stress response activation generates immunogenic peptides that may drive autoimmunity. The research will employ advanced molecular and translational techniques to profile stress-induced changes in protein homeostasis and characterize the production and presentation of neoantigens within the human leukocyte antigen (HLA) complex, with the ultimate goal of identifying distinct cytokine signatures and their effects on beta cell dysfunction across different stages of T1D progression.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 4/30/26 | ||
| Not listed | $178.0k | 4/29/26 |