Project Grant R03DK144282
- This $146,922 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The University of Pittsburgh is conducting research to investigate the role of gut protist-derived compounds on dietary antigen presenting dendritic cells in celiac disease. The project aims to understand how certain gut microbes can protect against virus-mediated loss of oral...
- This federal Project Grant award of $1,620,238 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund a research project at the University of North Carolina at Chapel Hill (UNC-CH) to detect regulatory variants and elements at type 2 diabetes genetic association signals across multiple tissues, including pancreatic islets, adipose, skeletal...
- This $882,180 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a comprehensive research effort to analyze the largest dataset of rare genetic variants associated with diabetes. The Broad Institute, Inc. will lead this project to assess variant penetrance and integrate the genomic data with high-throughput cellular assays to...
- This Project Grant award of $1,050,000 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a novel therapeutic solution for Celiac Disease (CED) using nanotechnology. The funded research focuses on formulating, manufacturing, and testing synthetic high-density lipoprotein nanodiscs for the controlled release of peptide antigens directly to lymph nodes. The goal is to...
- This $291,949 Project Grant was awarded on September 15, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant was awarded to Biosettia Inc. (UEI: GZM5S2UYEGD2) located in San Diego, CA to support research aimed at using deep sequencing to measure variants of the endogenous retrovirus (ERV) GAG gene as potential biomarkers for type 1 diabetes. The project seeks...
- This federal Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $4,239,889.00 to support the development of an oral enzymatic therapy adjunctive to the dietary management of celiac disease. The award is granted to Enteralia Bioscience LLC, located in Holden, MA, and has a performance period from Jul 1, 2024 to Jun 30, 2027. The overall objective of this research initiative is to develop an innovative oral...
- This Project Grant award of $248,915 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to unravel the role of epigenetics and cytokines in type 2 diabetes among African-ancestry populations in the U.S. and Europe. The research aims to identify causal associations between DNA methylation, circulating cytokines, and diabetes risk in these populations...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how exposure to food antigens leads to the formation of regulatory T cells and hyporesponsive conventional T cells in the gut. The $553,342 award to the Regents of the University of Minnesota will be used to study the underlying mechanisms, with the goal of identifying potential therapies for...
- This federal Project Grant award of $242,048 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research at Versiti Wisconsin, Inc. to investigate DNA damage responses and potential chromosomal abnormalities in hematopoietic stem and progenitor cells following genome editing. The goal is to enhance the understanding of genotoxicities and...
- This Project Grant award of $234,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Colorado-Denver to investigate the role of the Aiolos transcriptional regulator in the pathogenesis of inflammatory bowel disease. The researchers aim to utilize CRISPR-Cas9 genome editing to examine how Aiolos regulates T cell...
This $249,000 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to identify additional genetic factors that influence the clinical penetrance of the high-risk HLA-DQ2 or DQ8 alleles in Celiac Disease (CED). The research aims to uncover novel genetic risk factors that can enhance risk stratification and identify potential therapeutic targets for CED patients from diverse ethnic and genetic backgrounds. The award was made to The University of Texas Southwestern Medical Center, a prominent academic medical research institution located in Dallas, Texas. The project is scheduled to run from September 2025 through August 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 9/8/25 |