Project Grant R03DK144130
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- This federal Project Grant award, in the amount of $531,999.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is supporting research focused on understanding the role of alternative splicing in the proximal tubules of the kidney and its relationship to the progression of diabetic kidney disease. The research will investigate how diabetes...
- This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $659,182 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Rhode Island Hospital, a division of Lifespan Corporation. The funding will support research to elucidate the role and mechanism of histone deacetylase 6 (HDAC6) in cisplatin-induced kidney injury, fibrosis, and chronic kidney disease, and to identify HDAC6 inhibition as a novel approach for...
- This $532,177 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), supports research to investigate a novel inflammatory pathway in diabetic kidney disease (DKD). The research aims to elucidate the role of the transcription modulator I-MFA in regulating inflammatory cytokine production by glomerular mesangial cells, a key contributor to DKD pathogenesis. The 4-year project at the University of North Texas Health Science Center will...
- This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the molecular mechanisms driving the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). The $1,491,303 award to The Washington University aims to characterize how the repression of the FOXM1-CCNF axis during tubular epithelial...
- This Project Grant award of $633,272 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Tulane University to investigate the epigenetic mechanisms driving the lifespan and differentiation of nephron progenitor cells, with the goal of improving understanding and potential therapeutic approaches for renal regeneration. The...
- This $596,345 federal Project Grant was awarded on May 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Augusta University Research Institute, Inc. in Augusta, GA to investigate the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility in diabetic...
- This federal Project Grant award of $661,694, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to enhance the understanding of the role of the FANCD2 protein in kidney development, repair, and chronic kidney disease. The award supports research at The General Hospital Corporation, doing business as Massachusetts General Hospital, to investigate FANCD2's...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $739,540 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of Columbia University in the City of New York for the development and validation of a third-generation polygenic score (GPS) for chronic kidney disease (CKD). The goal is to improve personalized risk prediction and accelerate the clinical implementation of polygenic prediction in...
This $243,750 Project Grant was awarded on September 5, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the role of the protein DCLK1 in regulating the DNA damage response in proximal tubule cells, which are important mediators of chronic kidney disease (CKD). The research aims to characterize how increased DCLK1 expression in injured proximal tubule cells may help these cells evade apoptosis and repair DNA damage, but also how excessive DNA damage can lead to persistent activation of the DNA damage response pathway and secretion of inflammatory cytokines. This work is expected to provide insights into mechanisms driving CKD progression that could inform novel therapeutic approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $243.8k | 9/4/25 |