Project Grant R03DK141897
- This federal Project Grant award of $421,067.00, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research using kidney organoids to investigate the effects of in utero exposures, such as pregestational diabetes, on kidney development programs. The research aims to identify alterations to the normal differentiation of nephron progenitors and podocytes within the kidney...
- This federal Project Grant award of $168,886 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to elucidate the role of NAD+ and PARP1 in nephron endowment and kidney development. The 5-year project, awarded on May 1, 2025 with a completion date of January 31, 2030, will be conducted by the University of Texas Southwestern Medical Center. The...
- This Project Grant award of $633,272 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Tulane University to investigate the epigenetic mechanisms driving the lifespan and differentiation of nephron progenitor cells, with the goal of improving understanding and potential therapeutic approaches for renal regeneration. The...
- This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the molecular mechanisms driving the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). The $1,491,303 award to The Washington University aims to characterize how the repression of the FOXM1-CCNF axis during tubular epithelial...
- This federal Project Grant award of $661,694, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to enhance the understanding of the role of the FANCD2 protein in kidney development, repair, and chronic kidney disease. The award supports research at The General Hospital Corporation, doing business as Massachusetts General Hospital, to investigate FANCD2's...
- This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
- This $243,750 Project Grant was awarded on September 5, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the role of the protein DCLK1 in regulating the DNA damage response in proximal tubule cells, which are important mediators of chronic kidney disease (CKD). The research aims...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- This federal Project Grant award, in the amount of $531,999.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is supporting research focused on understanding the role of alternative splicing in the proximal tubules of the kidney and its relationship to the progression of diabetic kidney disease. The research will investigate how diabetes...
- This federal Project Grant award of $155,011 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting research to develop a deep learning model combining magnetic resonance (MAG3) renal scans and kidney ultrasound imaging data to more accurately diagnose unilateral ureteropelvic junction obstruction (UPJO) in children with antenatal hydronephrosis. The research...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to identify the progressive compositional, regulatory, and spatially defined signaling environments in mid to late-gestation primate nephrogenesis. The $240,978 award, granted to the Children's Hospital Medical Center in Cincinnati, Ohio, aims to leverage the molecular mechanisms enabling lateral branch nephrogenesis (LBN) to develop strategies to maintain and/or extend LBN-supporting signaling pathways in preterm infants. This research is critical as preterm birth is associated with decreased nephron endowment, leading to increased risk of chronic kidney disease and end-stage kidney disease. The project will utilize the rhesus macaque model, the sole known primate model that undergoes LBN like humans, to define the signaling pathways controlling this process.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $241.0k | 8/28/25 |