Project Grant R03DK140415
- This federal Project Grant award of $790,359, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The research project aims to design, characterize, and optimize a fibronectin-targeting, nanobody...
- This $172,232 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand the causes of inflammatory bowel disease (IBD) therapy failure. The principal investigator, Dr. Simon M. Gray, a gastroenterologist at the University of North Carolina at Chapel Hill, will leverage a pre-clinical mouse model to study the immunologic and...
- This $2,842,245 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the role of intestinal epithelial cell (IEC) injury pathways in governing anti-TNF therapy effectiveness for ulcerative colitis. The project aims to identify predictive biomarkers in formalin-fixed, paraffin-embedded (FFPE) patient biopsies that...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate gut microbial functions that impact Crohn's disease risk. Specifically, the $235,500 award to Rutgers, The State University of New Jersey will generate shotgun metagenomic sequencing data from samples collected from multiplex Crohn's disease families....
- This Project Grant award of $1,024,862.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The purpose of the award is to support the development of IMYX-3, a soluble small molecule RAB27A inhibitor, for the treatment of ulcerative colitis (UC). UC is a chronic inflammatory bowel disease affecting the colon, and...
- This federal Project Grant award of $358,039 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting research by Nous Biosciences Inc. to evaluate a combination therapy of dolcanatide (a guanylate cyclase-C agonist) and atiprimod (a JAK-STAT inhibitor) for the treatment of murine colitis. The research aims to advance understanding of the pathogenesis of...
- This Project Grant award of $191,547 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research conducted by Tufts Medical Center to evaluate the role of the gut mycobiome (fungal microbiome) in ulcerative colitis. The key objectives are to: 1) assess whether persistent elevations in the fungus Candida albicans in the gut predict failure of biologic therapies in ulcerative colitis...
- This federal Project Grant award, titled "Dietary Fiber-Microbiome Interactions: Elucidating Mechanisms to Suppress Multi-Drug Resistant Organisms in the Human Gut", was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $3,012,181 award to Duke University aims to conduct a longitudinal human study and computational modeling to understand how dietary fiber and the human gut...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $409,320.00 Project Grant to the University of California, San Diego (UCSD) to conduct research on immune adaptations in acute pouchitis, a common inflammatory condition affecting patients with ulcerative colitis. The grant, awarded on July 17, 2025, will support UCSD's use of single-cell RNA-sequencing and spatial transcriptomics to...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) totals $167,768 and aims to evaluate whether beta-lactam antibiotics increase the risk of acute kidney injury (AKI) in patients receiving immune checkpoint inhibitor (ICI) cancer treatments, compared to fluoroquinolone antibiotics. The award will support a target trial emulation study to assess this...
This Project Grant award of $250,056.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is supporting a pilot study at the University of North Carolina at Chapel Hill (UNC-CH) to evaluate the feasibility, safety, and tolerability of using the antibiotic rifaximin for the secondary prevention of pouchitis recurrence. The study aims to demonstrate the feasibility of recruiting and retaining patients, assess the safety and tolerability of rifaximin treatment, and explore differences in microbiome profiles between patients receiving rifaximin and an external control population. The award has a project period from September 15, 2025 to August 31, 2027 and will support the single-arm, open-label pilot study at UNC-CH.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $250.1k | 9/4/25 |