Project Grant R03DE035553
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded Trustees of Indiana University (Indiana University Indianapolis) $166,590 under the Oral Diseases and Disorders Research program (CFDA 93.121) on December 1, 2025. The recipient will conduct research on the function of zymogen granule 16B (ZG16B), a jacalin-related lectin protein, in salivary glands affected by oral inflammatory conditions...
- The National Institute of Dental and Craniofacial Research awarded The Trustees of Columbia University in the City of New York $329,000 on June 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to characterize the genetic and developmental mechanisms of mesencephalic trigeminal sensory cells in normal orofacial motor circuit maturation and in spinal muscular atrophy (SMA). The project investigates how sensory-motor circuits governing the transition from suckling to...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health within the Department of Health and Human Services, awarded $435,875 to Indiana University Indianapolis on July 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate oxylipin-mediated biofilm colonization in peri-implant disease. The research explores the role of oxylipins in regulating bacterial biofilm formation around dental implants. The study aims...
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute for Medical Research $124,200 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate ribosome biogenesis regulation of neural crest cell differentiation in development and disease. The funded research examines how ribosomal RNA transcription and ribosome biogenesis control neural crest cell fate acquisition and differentiation during craniofacial...
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute For Medical Research $371,250 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the pathogenesis, phenotypic variation, and prevention of craniofacial anomalies. The project examines how genetic and environmental factors interact to produce craniofacial birth defects—conditions such as cleft lip and palate, micrognathia, and craniosynostosis that account...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $128,191 to the University of California Irvine on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports a project grant (K99DE034828) to identify non-coding genetic sources of mammalian craniofacial variation and test their functional impact on facial morphogenesis. The research addresses the...
- The National Institute of Dental and Craniofacial Research awarded the University of California, Los Angeles $449,886 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research on the regulation of early mandibular morphogenesis by the homeobox protein MSX1. The research addresses craniofacial anomalies, which are among the most common congenital conditions. Mutations in the MSX1 gene are associated with tooth agenesis, cleft palate, and...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $249,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop bone-like organoids that elucidate how immune responses influence craniofacial bone healing and regeneration. The recipient will establish bone-like organoids as predictive tools for craniofacial bone repair...
- The National Institute of Dental and Craniofacial Research awarded the University of California, Davis $301,086 on July 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate cyclooxygenase signaling in neural crest migration and craniofacial development. The research identifies the role of cyclooxygenase (COX) signaling in regulating neural crest epithelial-to-mesenchymal transition, migration, and differentiation during embryonic development. The work...
- The National Institute of Dental and Craniofacial Research awarded The University of Kentucky Research Foundation $154,000 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to elucidate the etiology of Schneckenbecken dysplasia, a rare congenital skeletal disease caused by mutations in the SLC35D1 nucleotide-sugar transporter gene. The recipient will generate CRISPR models of patient-specific SLC35D1 variants using Xenopus tropicalis to understand how loss of...
The National Institute of Dental and Craniofacial Research awarded Trustees of Indiana University (Indiana University Indianapolis) $317,000 on August 1, 2026, through the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate perisynaptic Schwann cells and their role in protecting craniofacial neuromuscular junctions during amyotrophic lateral sclerosis disease progression. The research comprises two aims. Aim 1 defines the time course of ALS-induced neuromuscular junction degeneration in the masseter muscle using a novel NG2-DSRED fluorescent reporter mouse crossed with the mutant superoxide dismutase 1 (SOD1G93A) ALS model. High-resolution confocal imaging will assess perisynaptic Schwann cell coverage, neuromuscular junction morphology, and synaptic stability in the masseter, extraocular muscles, and gastrocnemius throughout disease progression. Aim 2 identifies molecular pathways of perisynaptic Schwann cell-mediated neuromuscular junction resilience or degeneration by isolating NG2-DSRED perisynaptic Schwann cells and performing single-cell RNA sequencing to characterize gene expression patterns associated with craniofacial muscle resistance to ALS-induced degeneration, compared to vulnerable hindlimb muscles. Period of performance runs from August 1, 2026, through July 31, 2028. Work is performed in Indianapolis, Indiana. This is a project grant, a form of assistance funding under NIDCR's extramural research portfolio supporting basic and translational research in dental, oral, and craniofacial health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $317.0k | 8/3/26 |