Project Grant R03DE034788
- This $619,477 federal Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to investigate the impact of electronic cigarette (e-cigarette) exposure, both direct and in-utero, on vascular function and cognitive decline. The research, conducted by the West Virginia University Research Corporation, aims to establish the dose-dependent effects of e-cigarette exposure on vascular dysfunction and...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $219,660 Project Grant to the Regents of the University of Michigan to conduct research on "Intercepting the Evolution of Pro-Tumoral Myeloid Cells During the Initiation of Oral Cancer". This project aims to investigate how myeloid cells in precancerous lesions develop suppressive phenotypes that inhibit anti-tumor immune...
- This federal Project Grant award of $619,175 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports a Type 1 hybrid effectiveness-implementation trial to evaluate a novel harm reduction approach for oncology outpatients who smoke but refuse traditional tobacco treatment. The study will directly compare rates of switching from cigarettes to e-cigarettes against standard care, while also assessing key barriers and facilitators to implementation. The...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $616,000 Project Grant to the Rowan University School of Osteopathic Medicine. This grant, with a performance period from Aug 1, 2025 to Jul 31, 2029, will support research investigating the use of the Hedgehog signaling pathway inhibitor drug sonidegib as a potential therapeutic strategy for oral squamous cell carcinoma (OSCC). The key...
- The federal Project Grant award titled "Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit" is funded by the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) for $663,554.00 with an award date of August 18, 2025 and an ultimate completion date of July 31, 2030. The grant supports research to explore the use of harm reduction product sampling, such as e-cigarettes, heated tobacco products, and oral...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $265,239 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of North Carolina at Chapel Hill (UNC-CH) to investigate the effects of vaping-induced oxidation on nicotine analogs in e-cigarettes. The project aims to evaluate the chemical composition of 6-methyl nicotine and nicotinamide vaping products before and after aerosolization, and assess...
- This Project Grant award of $315,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The goal of this 2-year project is to study the role of the TRPC1 protein as a potential therapeutic target for treating oral squamous cell carcinoma (OSCC), a common and deadly type of head and neck cancer. The research will focus on understanding how TRPC1 mediates calcium...
- This Project Grant award of $704,206 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The grant supports the development of an "organ on-a-chip" model to study oral cancer and bone invasion at Oregon Health & Science University. The key products and services to be delivered through this 5-year grant include: (1) systematically manipulating, characterizing, and...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $687,995.00 to Yale University to conduct a randomized clinical trial investigating the efficacy of varenicline (Chantix) for cessation of electronic cigarette (e-cigarette) use in adults. The study aims to test the hypothesis that varenicline is an effective intervention for helping e-cigarette users quit, given the addictive nature of nicotine in e-cigarettes and...
- This federal Project Grant award of $483,360.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to target vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry for developing new precision therapies for oral cancer. The project aims to explore synthetic lethal and gene interaction networks to expose druggable systems vulnerabilities and uncover mechanisms of...
This $317,000 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), to The Research Foundation for the State University of New York (RFSUNY), doing business as Stony Brook University. The grant aims to establish a screening system and identify histone modulation enzymes critical for e-cigarette-promoted oncogenes and pro-inflammatory genes, as well as to establish an animal model for testing chemoprevention of e-cigarette-accelerated oral squamous cell carcinoma (OSCC). The project will investigate how e-cigarettes with varied delivery methods and e-liquid compositions differentially accelerate OSCC carcinogenesis, induce oncogene-specific histone modulation in tumor cells, and modulate inflammatory gene expression. This research is intended to support the development of chemoprevention approaches for individuals with a history of cigarette smoking and oral premalignant lesions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $317.0k | 8/7/25 |