This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $583,289 to the University of Arkansas for Medical Sciences to conduct research on the epigenetic regulation of Kaposi's sarcoma-associated herpesvirus (KSHV) latency. The research aims to advance understanding of how KSHV, which causes several AIDS-defining malignancies including Kaposi's sarcoma, can...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $505,056.00 to the University of California, Davis to conduct research on the association between inflammatory tissue environment and Kaposi's Sarcoma-associated Herpesvirus (KSHV) replication. The research aims to understand how KSHV utilizes host cell "trained immunity" functions by inducing...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $466,640 to the University of Florida to investigate the mechanisms by which oral bacteria and their metabolites support Kaposi's sarcoma-associated herpesvirus (KSHV) infection in oral epithelial cells. The goal is to determine how bacterial factors, such as short-chain fatty acids, can upregulate cellular stress...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $1,337,014 over approximately 5 years starting September 1, 2024 to investigate the mechanisms by which Kaposi's Sarcoma-Associated Herpesvirus (KSHV) manipulates cellular metabolism to facilitate viral replication and tumor growth. The key research objectives are to: 1) Determine how KSHV's viral cyclin protein...
This Project Grant award of $877,104 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research to investigate the interactions between Kaposi's sarcoma-associated herpesvirus (KSHV), mononuclear phagocytes, and B cells, and how KSHV establishes long-term latency in B cells. The research, conducted by Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, will use computational...
This federal Project Grant award of $185,513, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), aims to develop O'PROTAC-based degraders that specifically target the KSHV-encoded LANA oncoprotein to interfere with the survival of Kaposi's sarcoma-associated herpesvirus (KSHV)-positive tumor cells. The award, with a project period from Nov 2024 to Oct 2026, is funding research at the University of Arkansas for Medical...
This $420,335 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research focused on understanding the role of lytic viral gene expression in the development and maintenance of oncogenic gammaherpesvirus-associated cancers. The University of Arkansas for Medical Sciences (UAMS) is leading this 2-year research project to test the hypothesis that lytic gene expression is...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Arizona in the amount of $118,763 for the period of September 1, 2024 to August 31, 2026. The grant will support Dr. Robert Jackson's research focused on assessing the role of human papillomavirus type 16 (HPV16) in transforming versus productive infections in oral epithelial tissues. The research aims to characterize the viral...
This federal Project Grant award of $429,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to determine the functional roles and mechanisms of the human microbiome and metabolome in the pathogenesis of oral squamous cell carcinoma (OSCC), a prevalent and lethal form of head and neck cancer. The research aims to 1) define OSCC-associated metagenomic and...
This federal Project Grant award of $339,000 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding supports research by New York University School of Medicine to investigate the role of autocrine cholinergic signaling in maintaining memory T cell responses in oral squamous cell carcinoma. The research project will be conducted from August 1, 2024 to July 31, 2026. As a leading...