The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $312,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan Office of Research and Sponsored Projects to establish the Michigan Collaborative Hub for TMD Patient-Centric Research (MICH T PCR). The goal of the award is to transform the treatment of temporomandibular disorders (TMDs) through the translation of clinically-relevant innovations. The...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $1,831,197 to Emory University to conduct research on nociplastic pain mechanisms in temporomandibular disorders (TMD). The research project aims to separate nociceptive (stimulus-evoked) sensitivity from pain sensitivity using novel quantitative sensory testing methods, in order to better understand the...
This $222,500 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research at The Children's Hospital of Philadelphia (CHOP) to investigate the pathogenic mechanisms of temporomandibular joint (TMJ) osteophyte formation. The key objectives are to test whether conditional ablation of the gene EXT1, which is involved in heparan sulfate synthesis, causes osteophyte formation...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,013,625.00 to the University of Pittsburgh to conduct research on developing a safe and effective replacement for the temporomandibular joint (TMJ) disc. The proposed research focuses on evaluating the long-term functional remodeling of a porcine small intestine submucosa (SIS) scaffold into a neo-disc in a...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...
This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
This Cooperative Agreement award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, will evaluate the safety and analgesic efficacy of a marine oil supplement containing specialized pro-resolving mediators for the treatment of chronic temporomandibular disorder (TMD) pain in adults. The $603,502 award will fund a 12-month, triple-masked, randomized, placebo-controlled clinical trial that...
This federal Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a randomized, placebo-controlled pilot study to evaluate the feasibility and potential efficacy of a novel temporo-masseteric nerve block (TMNB) injection in reducing post-surgical pain and improving jaw function following impacted third molar extractions. The $168,228 award to Rutgers, The State...
The University of Texas Health Science Center at Houston received a $722,040 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The grant, titled "FULLMOUTH: Enhancing Dental Clinical Data and Reducing Disparities Through Innovative ML Approaches", aims to utilize natural language processing and machine learning techniques to extract meaningful insights from...
This federal Cooperative Agreement award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research grant program (CFDA 93.121), aims to conduct multi-omic investigations of temporomandibular joint (TMJ) disorders. The $587,428 award will support a two-phase project at the University of California, Los Angeles (UCLA) to: 1) develop protocols and infrastructure for data management, subject recruitment, and sample collection; and 2)...