Project Grant R03DE033444

Award Date 7/1/24
Completion Date 6/30/26
Dollars Obligated $155K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This Project Grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research will fund $876,704 in research into DNA methylation's role in orofacial clefting. Led by the University of Wisconsin-Madison from August 2022 to August 2023, the project aims to advance understanding of epigenetic mechanisms in birth defects through several integrated studies. Researchers will apply genome-wide methylation and single-cell transcriptome approaches to a novel mouse...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports research to elucidate the roles of the protein p120-catenin in craniofacial development and disease. The $178,848 grant awarded to the University of California, San Francisco aims to leverage newly developed mouse models and live imaging approaches to understand the cellular behaviors and forces driven by...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $336,475 to the University of Missouri at Kansas City (UMKC) to study the impact of maternal dietary vitamin A on the risk and severity of cleft lip/palate in genetically predisposed embryos. The project aims to dissect the factors that influence cleft penetrance and severity in embryos genetically predisposed to cleft...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $508,390.60 to support research on the role of RNA polymerase III (Pol III) transcription in neural crest cell (NCC) development and craniofacial anomalies. The project aims to 1) analyze the effects of Pol III disruption on NCC proliferation, translation, and differentiation using patient-derived induced pluripotent...
This $320,053 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports a comprehensive research study on regulating skeletal connectivity in craniofacial development and disease. The primary awardee, the University of Southern California (USC), will leverage cutting-edge techniques in spatial transcriptomics and mouse genetics to identify genes and pathways that regulate...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $452,681 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Regents of the University of California, San Francisco (UCSF) for the project "Control of Mammalian Craniofacial Morphogenesis by the ESCRT Machinery." The research aims to determine the tissue-specific roles of the ESCRT machinery in regulating signaling pathways and lipid metabolism during mammalian craniofacial...
This $622,608 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the genomic and developmental mechanisms underlying Six2-related frontonasal dysplasia. The research aims to test the hypothesis that Six2-related frontonasal dysplasia is caused by disruption of topologically associating domains (TADs) that leads to misexpression of the neighboring Six3...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, provides $129,420 to The Leland Stanford Junior University to conduct research on regulating skeletal stem cell and neutrophil dynamics for improved cleft palate bone regeneration. The key objectives are to: 1) Identify how bone morphogenetic protein-2 (BMP-2) based palatal and mandibular bone regeneration is regulated by...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $148,760 to the University of Southern California (USC) to investigate the roles of two genes, HSD3B7 and FOXP2, in regulating jaw development. The research aims to uncover novel mechanisms by which these genes function upstream and downstream of hedgehog signaling to pattern the connective tissues, such as...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $455,939 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Massachusetts Lowell. The award period is from July 1, 2024 to June 30, 2027. The project will investigate the molecular and cellular mechanisms underlying how dosage of the signaling factor FGF8 impacts the development of the jaw and skull, including the formation and separation of the first pharyngeal...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, provides $154,602 to the University of Pittsburgh to develop and study an existing mouse model of cleft lip and palate with known epigenetic contributions. The research aims to directly relate DNA methylation, gene expression, proliferation, and morphology in a single embryo to understand how genetically identical individuals can develop differing developmental trajectories, including the presence or absence of this structural birth defect. The first aim focuses on identifying the gene(s) responsible for the epigenetic modification and understanding how it functions as a modifier of the cleft lip phenotype. The second aim involves building imaging tools and computational models to understand how changes in cellular properties, such as proliferation and apoptosis, can lead to the cleft lip and palate phenotype. This research is expected to expand the understanding of epigenome-phenotype relationships and the mechanisms underlying orofacial clefting.

Generated 4/1/25, 4:30 AM