Project Grant R03DA064666
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of California, San Diego a $197,500 Project Grant effective September 1, 2025, through August 31, 2027, under the Drug Use and Addiction Research Programs (CFDA 93.279). This award supports the development and validation of an in vivo Massively Parallel Reporter Assay (MPRA) designed to analyze the functional role of cis-regulatory elements and genetic variants associated with substance use disorders...
- Federal Grant Award Summary The University of California, San Diego received a $1.39 million Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate mitochondrial dysfunction as a therapeutic target in HIV-associated neurocognitive disorders and opioid use disorder. The award, obligated on March 1, 2026 with a completion date of December 31, 2030, funds research examining dysregulated oxidative...
- Federal Grant Award Summary Award Details: The National Institute on Drug Abuse (NIDA) awarded $877,500 to the University of California, San Diego under the Drug Use and Addiction Research Programs (CFDA 93.279) Project Grant mechanism on July 15, 2025, with a completion date of June 30, 2027. Research Deliverables: This project delivers basic research investigating the neurobiological mechanisms underlying cocaine use disorder (CUD) susceptibility through a novel predictive methodology called...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of California, San Diego a $3.73 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning April 15, 2025, with a completion date of January 31, 2030. This research initiative investigates the mechanistic intersection of human immunodeficiency virus (HIV) and opioid use on inflammasome-mediated neuroinflammation and neurotoxicity in the central nervous system...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded UC San Diego a Project Grant of $2,250,249 (awarded September 20, 2025, with completion by August 31, 2029) under the Alcohol Research Programs (CFDA 93.273) to conduct longitudinal magnetic resonance imaging (MRI) studies investigating brain features associated with alcohol use disorder (AUD). The research employs a large cohort of 100 genetically diverse outbred rats with variable vulnerability...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $126,660 Project Grant to the University of California, San Diego on September 30, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research on the genetic mechanisms underlying addiction-related behaviors. The project, titled "Unraveling the Role of Tandem Repeats and Structural Variants in Addiction-Related Behaviors Using Heterogeneous Stock Rats," will deliver research...
- Federal Grant Award Summary The University of California, San Diego received a $200,446 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective May 15, 2025 through April 30, 2030. This award supports a mixed-methods research study examining the association between novel housing programs and overdose outcomes among unhoused people who use drugs (PWUD) in San Diego, California. The research addresses a...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $650,250 Project Grant to the University of California, Irvine, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a five-year investigation into the neural mechanisms underlying motivational and cognitive impairment during opioid withdrawal. The research will deliver scientific products examining how dopamine (DA) and acetylcholine (ACH) signaling adaptations in the nucleus accumbens and...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $811,112 Project Grant to the Regents of the University of California, San Francisco effective July 1, 2025 through March 31, 2030 under the Drug Use and Addiction Research Programs (CFDA 93.279). This neuroscience research project investigates the network and circuit dynamics supporting dopaminergic control of sudden insight learning in cue-reward associations. The research combines advanced neuroimaging...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of California, Berkeley $800,617 under the Drug Use and Addiction Research Programs (CFDA 93.279) for a Project Grant commencing June 1, 2025 and concluding February 28, 2030. This research initiative focuses on the development and validation of neuromarkers—measurable, brain-based indicators of pathophysiology, risk, and resilience—to advance understanding and treatment of substance use disorders...
UC San Diego received a $239,125 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded March 1, 2026, with completion targeted for February 28, 2027. The award supports longitudinal multiparametric magnetic resonance imaging (MRI) research to characterize brain features associated with opioid use disorder (OUD) in genetically heterogeneous rats with variable vulnerability to oxycodone addiction-like behaviors. The research leverages rats from the NIDA-funded Rat Oxycodone Biobank (U01DA051937) that have fully characterized genomes and documented addiction-related behavioral responses to extended intravenous oxycodone self-administration. The research deliverables include comprehensive neuroimaging assessments using structural, diffusion, and functional MRI to identify individual differences in brain architecture and function at baseline (pre-oxycodone exposure) and during acute withdrawal following extended oxycodone access. This pilot study establishes MRI imaging capabilities within the recipient's research environment and generates preliminary data for larger follow-up investigations examining interactions between pre-existing brain features and oxycodone-induced neurobiological changes. The work advances translational research by combining preclinical whole-brain imaging approaches with clinically relevant neuroimaging methodologies to inform human applications in substance use disorder research.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $239.1k | 2/20/26 |