The Washington University Office of Sponsored Research Services Division has been awarded a $645,323 Project Grant from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) to conduct research on the mechanisms of acid signaling in bone metastases and its impact on tumor progression and immune suppression. The goal of this 5-year project is to investigate how acid production and associated signaling pathways in tumor cells and myeloid cells contribute to the evolution of an immune-suppressive tumor microenvironment in bone metastases. The research will use genetic and pharmacological approaches to disrupt acid-induced G-protein signaling in order to enhance sensitivity to immunotherapy and reduce bone tumor burden and destruction. The findings from this study have the potential to lead to novel therapeutic strategies for improving outcomes in breast cancer patients with bone metastases.
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