This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $163,319.00 to the University of California, Irvine to investigate how disruption of the circadian clock impacts the immune system and promotes the development of colorectal cancer. The project aims to determine how clock disruption alters the immune landscape, leading to immunosuppression and accelerating tumorigenesis. Specific objectives include examining the impact of clock...
This Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) provides $590,960.00 in funding to the Beckman Research Institute of the City of Hope to conduct research aimed at improving the understanding and treatment of acute myeloid leukemia (AML). The key objectives of the project are to: 1) Quantify the dynamics of leukemia potential driven by different oncogenic signals in murine models, 2) Evaluate the effects of treatment on leukemia...
This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) to Northwestern University provides $187,000.00 in funding from March 10, 2025 to February 28, 2027. The grant supports research to investigate how lipid metabolism and epigenetic reprogramming in breast tissue may contribute to the development of estrogen receptor-negative breast cancer. Key objectives include exploring the expression of neural genes, identifying histone...
This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) provides $132,825 to the Sloan-Kettering Institute for Cancer Research to develop and validate prognostic models for Black women with endometrial cancer following hysterectomy. The key goals are to: Build a robust prognostic tool to predict 3- and 5-year survival for Black endometrial cancer patients post-hysterectomy, and externally validate this tool. Compare its performance to an...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $483,077 to Baylor College of Medicine to conduct research on how the noncanonical clock transcription factor ESRRG regulates circadian enhancer-promoter interactions in the progression from nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). The 5-year project, beginning June 1, 2025, will use mouse models and human liver samples to investigate how ESRRG...
This Project Grant award from the National Cancer Institute (NCI), under the federal Cancer Cause and Prevention Research program (CFDA 93.393), provides $577,529 to Health Research, Inc. to investigate the relationship between accelerated ribosomal DNA (rDNA) methylation age and early-onset prostate cancer in African American patients. The main objectives are to: 1) determine if African American prostate cancer patients exhibit higher rDNA methylation age at diagnosis compared to age-matched...
This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $595,374.00 to the University of Vermont & State Agricultural College to identify gene expression profiles that can predict late recurrence risk for estrogen receptor-positive breast cancer patients. The project aims to analyze gene expression data from 200 cases of late distant breast cancer recurrence and 200 matched controls to develop a predictive model for...
This federal Project Grant award of $505,613 from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) will fund the development of statistical and computational approaches to leverage genomic data for precision cancer prevention. The key products and services to be delivered include: Deep learning-based methods to identify tumor heterogeneity and predictive biomarkers of aggressive cancer, integrating spatial omics data. Statistical...
This $2,372,456 Project Grant awarded by the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) will support a collaborative research program led by Memorial Sloan Kettering Cancer Center focused on leveraging observational (real-world) data to advance precision oncology. The key products and services to be delivered include: Overcoming methodological barriers in the analysis of observational clinico-genomic data (Project 1) Addressing the role of genetic ancestry...
This Project Grant award for $527,159 from the National Cancer Institute (NCI), under the federal Cancer Biology Research program (CFDA 93.396), supports research to understand the fundamental biological mechanisms underlying the initiation and development of breast cancer in individuals with BRCA1 mutations. The key focus is on examining how DNA damage and aberrant cell fate changes in BRCA1-deficient mammary epithelial cells, particularly luminal progenitor cells, may lead to a...