Emory University received a $659,498 federal Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) to study racial disparities in prostate cancer metastasis. The key objectives are to:
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Analyze differential pathway activity related to oxidative phosphorylation (OXPHOS) and the FGFR3 signaling pathway in diverse patient cohorts to understand their association with African ancestry and metastasis.
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Investigate the impact of perturbing FGFR3 signaling on metastasis using in vitro and in vivo models of African American prostate cancer.
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Determine the effect of manipulating OXPHOS activity on the metastatic potential of African American prostate cancer cell lines.
This 5-year research project aims to provide new insights into the biological mechanisms driving prostate cancer disparities in African American men, with the potential to identify therapeutic targets and interventions to help reduce this significant health disparity.
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