Project Grant R03AI185405
- Federal Grant Award Summary Award: Therapeutic Potential of Mycobacteriophage LYSB Against Mycobacterium Abscessus Infections The National Institute of Allergy and Infectious Diseases (NIAID) awarded Health Research, Inc.'s Wadsworth Center Division a $1.38 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 18, 2025, with completion targeted for June 30, 2030. This research initiative aims to develop D29 mycobacteriophage lysin (LYSB) as a...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $486,470 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period August 11, 2025 through July 31, 2027. The award funds the development and validation of direct-from-sample whole genome sequencing (WGS) methods for Neisseria gonorrhoeae (NG) that eliminate the need for isolate culturing. These methodological advances will be applied to generate...
- Project Grant Summary Brigham and Women's Hospital received a $198,630 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2030. This award supports the development and validation of BADLOCK, a CRISPR-based diagnostic assay designed to rapidly identify bacterial species and antimicrobial resistance (AMR) genes from blood cultures in...
- L2 Diagnostics LLC received a $293,142 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 21, 2025, with a completion date of August 31, 2027. The award supports development of a rapid diagnostic test (RDT) in lateral flow assay (LFA) format for detecting Babesia microti infection. The test targets BMGPI12 (BMSA1), a secreted protein released into the...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award supports the development of a novel device that can rapidly and automatically extract pathogen DNA from whole blood samples to enable faster diagnosis of sepsis. The $274,858 award to New England Hemolytics, Inc., with a project period from September 1, 2024 to February 28, 2025, will fund the testing and optimization of this technology across common sepsis-causing pathogens. The...
- Federal Grant Award Summary SKM Instruments, LLC received a $797,550 Project Grant from the Centers for Disease Control and Prevention (CDC) under the Prevention of Disease, Disability, and Death by Infectious Diseases program (CFDA 93.084) to develop an ultra-rapid optical platform for antimicrobial susceptibility testing (AST) of pulmonary non-tuberculous mycobacterial (NTM) infections. The award, effective September 30, 2025, with a completion date of May 31, 2026, supports research and...
- Federal Project Grant Award Summary Tufts Medical Center Parent, Inc. (Tufts Medical Center) received a $190,768 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 2, 2025, through August 31, 2028. The award funds development of a rapid transcriptomic assay for antimicrobial susceptibility testing (AST) of Mycobacterium abscessus, a nontuberculous mycobacterium...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Health Research, Inc.'s Wadsworth Center Division a $403,756 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on April 14, 2026, for completion by March 31, 2028. This research initiative focuses on mapping the determinants of bedaquiline (BDQ) resistance in Mycobacterium tuberculosis (MTB), an extensively drug-resistant pathogen. The project delivers a...
- Federal Cooperative Agreement Summary Seek Laboratories, Inc. received a $2.0 million Cooperative Agreement from the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025), awarded February 2, 2026, with completion targeted for December 31, 2028. The award supports the development of a programmable CRISPR gene-editing platform designed to combat highly pathogenic avian influenza...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital $473,937 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 25, 2025, for a project period extending through June 30, 2027. The award supports development of a novel point-of-care liquid biopsy diagnostic tool for early detection of sepsis-associated organ damage. The project leverages the institution's pioneering liquid biopsy...
NEW APPROACHES TO SEQUENCE GENOMES OF MYCOBACTERIUM LEPRAE FROM CLINICAL AND FIELD SPECIMENS - PROJECT SUMMARY CULTURE-BASED DIAGNOSTICS FOR THE LEPROSY-CAUSING AGENT MYCOBACTERIUM LEPRAE ARE CHALLENGED BY OUR INABILITY TO CULTURE THE PATHOGEN IN VITRO. MOREOVER, OBTAINING A SUFFICIENT QUANTITY OF BACILLI RELIES ON IN VIVO MODELS SUCH AS MICE OR ARMADILLOS IN A PROCESS THAT REQUIRES SIGNIFICANT RESOURCES AND TIME BECAUSE OF THE SLOW GROWTH OF THE PATHOGEN. THIS EXTENDED TIMEFRAME, COUPLED WITH OUR INABILITY TO ENGINEER RECOMBINANT M. LEPRAE STRAINS IN VITRO, PRESENTS SIGNIFICANT OBSTACLES TO INVESTIGATING THE MECHANISMS BEHIND ITS PATHOGENICITY AND DRUG RESISTANCE. FURTHERMORE, TO THOROUGHLY STUDY M. LEPRAE'S EPIDEMIOLOGY, TRANSMISSION, AND EVOLUTION, IT IS IMPERATIVE TO SEQUENCE M. LEPRAE STAINS FROM ALL CLINICAL AND FIELD ORIGINS. HOWEVER, OBTAINING SUFFICIENT BACTERIAL DNA FROM HUMAN AND ANIMAL SAMPLES IS CHALLENGING. OVER THE PAST DECADE, EXTENSIVE EFFORTS HAVE BEEN DEDICATED TO ENHANCING OUR ABILITY TO SEQUENCE M. LEPRAE GENOMES. CURRENTLY, TWO METHODS ARE EMPLOYED FOR THIS PURPOSE, BUT THEY ARE LIMITED IN EITHER THEIR SENSITIVITY, APPLICABILITY TO DIFFERENT TISSUE SAMPLES, OR HIGH COST. AS A RESULT, THESE LIMITATIONS ARE CURRENTLY IMPEDING THE WIDESPREAD USE OF GENOME SEQUENCING IN LEPROSY RESEARCH. WE PROPOSE TO DEVELOP A NEW METHOD BASED ON THE SELECTIVE WHOLE GENOME AMPLIFICATION (SWGA) OF A MINUSCULE QUANTITY OF M. LEPRAE DIRECTLY FROM COMPLEX SAMPLES. OUR PRELIMINARY DATA ON DNA COLLECTED FROM LABORATORY-INFECTED ARMADILLOS SHOWS THAT SWGA COULD COMBINE SENSITIVE, ACCURATE, EASY-TO-IMPLEMENT, AND COST-EFFECTIVE CHARACTERISTICS TO SUCCESSFULLY SEQUENCE M. LEPRAE FROM COMPLEX SAMPLES. THIS EXPLORATORY PROJECT AIMS TO DEVELOP THE SWGA METHOD AND COMPARE IT WITH THE GOLD STANDARD BAIT CAPTURE TO VALIDATE ITS USE TO SEQUENCE THE GENOME OF M. LEPRAE FROM INFECTED HUMANS AND ANIMALS. AIM 1 WILL EVALUATE THE SENSITIVITY AND ACCURACY OF SWGA COMBINED WITH SHORT-READ SEQUENCING AND ITS APPLICABILITY TO LONG-READ SEQUENCING ON M. LEPRAE DNA EXTRACTED FROM LABORATORY AND NATURALLY INFECTED ARMADILLO TISSUES. AIM 2 WILL GENERATE AND VALIDATE THE NECESSARY REAGENTS TO PERFORM SWGA ON M. LEPRAE DNA EXTRACTED FROM INVASIVE (SKIN BIOPSY) AND NON-INVASIVE (NASAL SWAB) HUMAN SAMPLES.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 1/22/26 | ||
| Not listed | $77.1k | 5/12/25 | ||
| Not listed | $77.1k | 5/12/25 | ||
| Not listed | $9.1k | 9/11/24 | ||
| Not listed | $9.1k | 9/11/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
G1098601S | University Of Mississippi Medical Center | Project Grant R03AI185405 | $15.0k | 10/27/25 | |
G1098601S | University Of Mississippi Medical Center | Project Grant R03AI185405 | $36.2k | 12/19/24 |