This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,273 in funding to the University of Massachusetts Medical School to investigate how the Herpes Simplex Virus 1 (HSV-1) regulates the NLRP1 inflammasome pathway and contributes to antiviral defense in human skin. The goals of this 5-year project are to: 1) determine how the HSV-1 ICP0 protein activates...
This federal Project Grant award of $651,832 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate how the herpes simplex virus (HSV-1) manipulates the host cell's DNA damage response and proteome to promote viral gene expression and replication. The research team at The Children's Hospital of Philadelphia will use multi-modal proteomics techniques to define how changes to...
This $881,878 federal Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award aims to study the cross-talk between skin-resident T-cells (CD8 T resident memory cells) and keratinocytes, the primary target of herpes simplex virus (HSV) infection, to understand how this interaction influences HSV recurrence. The research will utilize advanced techniques such as single-cell RNA...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $236,292 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Tufts University School of Medicine to capture and characterize the structural complexes of the herpes simplex virus (HSV) glycoproteins critical for viral entry. The project aims to use new methods to isolate and analyze the 3D structures of the GD/GH/GL and GH/GL/GB glycoprotein complexes involved in HSV cell entry, which have been...
This $107,948 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to investigate the local and systemic coordination of antiviral immunity by tissue-resident memory CD8 T cells in the skin. The two-year project, running from February 1, 2025 to August 25, 2027, aims to determine whether CD8 tissue-resident memory T cells in the skin can orchestrate an immune...
This $471,159 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the mechanisms by which alpha herpesviruses, such as herpes simplex virus-1 (HSV-1), invade the peripheral nervous system. The 5-year research project, awarded to the University of California, Irvine, aims to investigate how the response of peripheral nerve axons to the cytokine...
This Project Grant award, valued at $215,810 and funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the mechanisms by which the herpes simplex virus type 1 (HSV-1) degrades host proteins in neurons to enable viral replication and reactivation from latency. The primary awardee, the University of Virginia, will collaborate with the University of Cambridge to: 1)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,486,800.00 to the Albert Einstein College of Medicine to conduct research on the role of TNFRSF14 signaling in promoting antibody-dependent cell-mediated cytotoxicity (ADCC) for herpes simplex virus (HSV) vaccine development. The project aims to identify the signaling pathways and structural determinants that...
This $126,174 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to investigate local immune responses and granulopoiesis (neutrophil production) in human skin in response to bacterial infections. The project aims to: 1) Demonstrate the role of the SDF-1/CXCR4 signaling axis in attracting and maintaining hematopoietic stem and progenitor cells (HSPCs) in the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on developing a potentially curative gene editing therapy for latent Herpes Simplex Virus Type 2 (HSV-2) infection. The $303,731 award to Caladan Therapeutics, Inc. aims to select and validate a lead meganuclease variant that can specifically target and eliminate HSV-2 from latently infected ganglionic neurons, which...