Project Grant R03AG095868
- The National Institute on Aging (NIA) has awarded a $640,906 project grant under CFDA 93.866 Aging Research to the University of Wisconsin-Madison to conduct research on "Elucidating Cerebrovascular Disease Pathways to Cognitive Decline with Vascular Neuroimaging." The 5-year project aims to utilize advanced neuroimaging techniques to understand the vascular contributions to cognitive impairment and dementia (VCID), and assess their relationship to Alzheimer's disease proteinopathy....
- This federal Project Grant award, valued at $1,552,000.00 and provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a research study examining the relationship between markers of vascular and immune dysfunction, such as platelet aggregation and neutrophil levels, and their association with dementia risk and increased Alzheimer's disease (AD) biomarkers. The study, conducted by New York University School of Medicine, aims to integrate biofluid biomarker data with...
- This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $156,512 project grant to the Regents of the University of Minnesota, to be completed by September 29, 2025. The grant will support research investigating the role of lipid aldehydes in inducing cellular senescence in adipose tissue, a key factor in age-related metabolic dysfunction. The proposed studies aim to characterize the biochemistry and signaling mechanisms underlying this...
- This federal Project Grant award of $2,586,818.00 was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to the Fred Hutchinson Cancer Center in Seattle, Washington. The grant aims to elucidate the mechanisms of communication between adipocytes (fat cells) and the brain, and their impact on glial cell function, neuroprotection, and brain aging. The research will focus on investigating how adipocyte-derived lipoproteins and mitochondrial signals influence...
- This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
- This Project Grant award of $1,602,696 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the relationship between obesity, cognitive impairment, and neurological disorders such as Alzheimer's disease. The research aims to use magnetic resonance imaging (MRI) techniques to assess neurovascular and lymphatic changes, neuroinflammation, and blood-brain barrier dysfunction in mouse models of obesity-linked cognitive decline. The goal is to identify...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
- The National Institute on Aging (NIA) awarded a $400,707 Project Grant (CFDA 93.866 - Aging Research) to the University of Florida to map brain lipid architecture in aging, Lewy body dementia (LBD), and T-cell therapy. The 2-year grant, running from September 1, 2024 to August 31, 2026, will utilize novel imaging mass spectrometry to generate a spatial atlas of the lipidome and identify lipid markers of disease progression in LBD. The research aims to assess lipid alterations resulting from an...
This federal Project Grant award of $286,000 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), aims to investigate how age-related lipid dysregulation in brain endothelial cells contributes to cognitive impairment. The research will assess the effects of lipid droplet accumulation on endothelial structure and function, and evaluate how this impacts microvascular aging and cognitive decline. The award was made to the University of Oklahoma Health Sciences Center and will run from September 15, 2025 through August 31, 2027. The research seeks to advance scientific understanding of the links between lipid metabolism, endothelial dysfunction, and age-related cognitive impairment, with the goal of identifying potential therapeutic targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $286.0k | 9/9/25 |