Project Grant R03AG095395
- This Project Grant award of $257,040.00 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to investigate the role of Alzheimer's disease pathology in mild behavioral impairment (MBI). The key products and services to be delivered include: Examining the network-level structure-function relations associated with MBI (Aim 1) and assessing the association between blood-based Alzheimer's disease biomarkers, MBI symptoms, and network-level...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will provide $128,321 to the Regents of the University of Michigan to conduct research on retrosplenial cortex circuits in preclinical models of Alzheimer's disease. The project aims to systematically dissect the retrosplenial cortex circuitry, with a focus on understanding how a specific cell type called "low-rheobase" cells and their inputs from the...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
- This Project Grant award of $640,067 from the National Institute on Aging (CFDA 93.866 Aging Research) will fund the development of novel multimodal variational autoencoder (VAE) models to learn factors associated with cognitive resilience to Alzheimer's disease (AD) and related dementias. The University of Michigan, the awardee, will employ generative methods to discover new factors from existing multimodal data (molecular, anatomic, functional imaging, cognitive) and model dynamic...
- This Project Grant award for $301,417 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the University of Arizona. The award aims to develop innovative methods and tools for integrating data from Alzheimer's disease and related dementias (AD/ADRD) studies to address challenges posed by inconsistencies among evidence from different studies, particularly for comparative effectiveness research. The project has two main...
- This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
- This Project Grant award of $4,787,820.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a better understanding of the individual- and system-level characteristics that influence diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), and how diagnosis can moderate the effects of cognitive decline on employment, future care, and quality of life. The key objectives are to: 1) examine whether older adults experiencing...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Southern California provides $622,401 over 5 years starting January 1, 2025 to research causal models of brain biomarker changes leading to Alzheimer's disease and related dementias (ADRD). The project aims to: 1) fit novel deep learning models to predict ADRD pathology from diffusion MRI data, 2) generate individualized brain morphology prediction maps as "digital...
- This $2,288,528 federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to improve cross-national measurement of mild cognitive impairment (MCI) and characterize its longitudinal course across diverse populations in the U.S., Mexico, and India. The study will harmonize MCI and dementia diagnoses, compare MCI prognosis, and investigate sociodemographic, lifestyle, health, and biological risk factors associated with MCI and dementia across...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $156,000.00 to the Regents of the University of Michigan, to be completed by April 30, 2027. The project aims to evaluate a mild behavioral impairment (MBI) diagnostic framework and map structural brain network changes associated with MBI in early-stage Alzheimer's disease and related dementias (ADRD). Specifically, the project will define network-level structural alterations linked to MBI in cognitively unimpaired and mild cognitive impairment populations (Aim 1), and quantify the predictive value of MBI-related structural network changes for dementia conversion (Aim 2). This research leverages data from the National Alzheimer's Coordinating Center (NACC) to advance understanding of the neural correlates of MBI and its relationship to the development of ADRD, with the goal of improving early detection and prevention strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $156.0k | 8/4/25 |