Project Grant R03AG090954
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,375.00 to support research on the role of the GPR37L1 receptor in chronic migraine. The funding will enable a research team at Florida Atlantic University, with a sub-award to the University of Florida, to conduct a comprehensive investigation into the involvement of GPR37L1 signaling in the neuropathology of...
- This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This Project Grant award of $257,040.00 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to investigate the role of Alzheimer's disease pathology in mild behavioral impairment (MBI). The key products and services to be delivered include: Examining the network-level structure-function relations associated with MBI (Aim 1) and assessing the association between blood-based Alzheimer's disease biomarkers, MBI symptoms, and network-level...
- This $792,498 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research by the Trustees of Indiana University, doing business as Indiana University Indianapolis, to investigate the role of P2X7 receptor signaling in neuroinflammation and neurodegeneration in Alzheimer's disease and related dementias (ADRD). The key objectives are to: 1) characterize mouse models of ADRD to assess neuroinflammation, synaptic density, and neuronal health...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $848,286 to the University of South Florida to conduct research on the role of N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease (AD). The key objectives are to: 1) Create a high-resolution map of m6A sites in the brains of older adults, 2) Identify specific m6A alterations associated with AD and its clinical/pathological features, and 3) Elucidate how m6A dysregulation may...
- This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $372,400 to Nova Southeastern University to conduct research comparing the therapeutic potential of three compounds - tirzepatide, retatrutide, and crocetin - in mitigating Alzheimer's-like pathology in a mouse model of comorbid Alzheimer's disease and obesity/prediabetes. The 3-year study, running from December 2024 to November 2027, will assess the impact of these interventions on...
- The National Institute on Aging (NIA) awarded a $6,670,032 Cooperative Agreement under the Aging Research Federal Grant Program (CFDA 93.866) to the Trustees of Indiana University (doing business as Indiana University Indianapolis) on July 1, 2025. The award supports the development of reproducible, scalable, and standardized 3D brain organoid-based microphysiological systems (MPS) models that recapitulate key features of human Alzheimer's disease (AD) and Alzheimer's disease related dementias...
This Project Grant award of $317,000 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), supports research to determine how chronic migraine accelerates the development of Alzheimer's disease (AD) pathology and cognitive decline in a preclinical mouse model of AD. The key objectives are to: 1) Assess the impact of chronic migraine on multiple domains of cognition in an AD mouse model using clinical tests, and 2) Analyze gene and protein expression patterns to determine if migraine advances the activation of pathways associated with AD progression. This research aims to provide a better mechanistic and behavioral understanding of how the overlap in neuroinflammatory pathways between migraine and AD contributes to increased AD incidence observed in migraine patients. The award has a performance period from September 1, 2025 to August 31, 2027 and is being conducted by the Trustees of Indiana University.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $317.0k | 8/26/25 |