Project Grant R03AG090922
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $400,000.00 in funding to Baylor College of Medicine to conduct research on the cellular and molecular mechanisms that govern bladder aging. The key objectives are to: Define the role of ribosomal and translational quality control machinery in maintaining bladder homeostasis and response to urinary tract infections in young, aged, and genetically-modified mouse models. This includes using a 3D...
- The National Institute on Aging (NIA) awarded a $489,509 Project Grant (CFDA 93.866 - Aging Research) to the Magee-Womens Research Institute And Foundation to conduct research on steroid hormone pathways regulating benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with aging. The 2-year project aims to: Identify proteins and pathways involved in promoting smooth muscle relaxation and bladder voiding that are dysregulated in aged mouse prostate models and...
- This Project Grant award, valued at $2,129,396.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award aims to develop and validate engineered adeno-associated viruses (AAVs) that can selectively knock down the follicle-stimulating hormone receptor (FSHR) in neurons within brain regions vulnerable to Alzheimer's disease. This research seeks to understand the role of FSH signaling in cognitive decline and Alzheimer's...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
- This $4,765,698 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund a research study by the University of California, Santa Barbara to investigate the effects of endocrine aging on spatial navigation ability and its neuronal systems. The project will enroll 240 cognitively normal midlife adults, with a balanced distribution of pre-, peri-, and post-menopausal women, and use immersive virtual environments and brain imaging to elucidate how...
- The federal Project Grant award R21AG086723 for $466,125.00 was granted by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine to characterize age-related changes in the testis stem cell niche. The key objectives are to: (1) identify genes differentially expressed in young and aged testis niche cells and those dependent on activin signaling, and (2) develop new tools to monitor activin and follistatin proteins and pathway activity in the fly...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This $721,089.02 federal Project Grant award from the National Institute on Aging (part of the National Institutes of Health) under the Aging Research program (CFDA 93.866) will support research to delineate how epigenetic regulation of the ACVR1C gene contributes to age- and Alzheimer's disease-related memory impairments in females and males. The goal is to determine if ACVR1C functions as a self-regulating mechanism underlying these cognitive declines, and if overriding ACVR1C impairment can...
- This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $3,005,541.00 to Baylor College of Medicine to conduct research on the mechanisms driving age-dependent and sex-dependent changes in bladder immunity that contribute to recurrent urinary tract infections (UTIs) and other lower urinary tract disorders in older women. The...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $2,612,229 to the University of Delaware to conduct research on the benefits and harms of different hypertension management strategies for nursing home residents with Alzheimer's disease and related dementias (ADRD). The 4-year project, running from Sep 1, 2025 to Aug 31, 2029, aims to: 1) describe current hypertension treatment approaches in this...
This federal Project Grant award of $162,200.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award supports a pilot study to investigate the age- and sex-based changes in vasopressin signaling, with a focus on the expression of vasopressin 2 receptors (V2R) in the kidney and bladder of the fruit bat (Carollia perspicillata). The study aims to establish the prevalence of nocturia (frequent nighttime urination) in the bat colony and determine the impact of the vasopressin analogue desmopressin on urine output, osmolality, and bladder function in young and elderly bats of both sexes. This research may provide insights into the underlying mechanisms of nocturia, which has a significant negative impact on sleep and health, particularly in the elderly. The award was made to The Research Foundation For The State University Of New York, doing business as SUNY Downstate Health Sciences University, and the project period runs from August 15, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $162.2k | 8/6/25 |