This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how Alzheimer's disease pathogenesis interferes with synaptic autophagy, and evaluate if optimizing synaptic autophagy can be neuroprotective in an Alzheimer's mouse model. The $628,000 award to Rutgers, The State University of New Jersey, will utilize primary hippocampal cell cultures and mouse models to study the disruption of autophagic processing of synaptic proteins in...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $795,436 to Rutgers, The State University of New Jersey to study the role of the glycoproteome in Alzheimer's disease and related dementias (AD/ADRD). The key products and services delivered under this award include:
Using a novel glycoproteome-wide analysis method to identify glycopeptiforms (sugar-modified proteins) related to AD/ADRD pathologies and clinical traits, including...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $652,575 provides funding to New York University School of Medicine to conduct research on the disruption of endosomal microautophagy (EMI) by pathological tau protein in Alzheimer's disease (AD). The key objectives are to 1) elucidate the role of pathological tau in destabilizing the EMI pathway, 2) identify which EMI components are most vulnerable to tau pathology, and 3)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $226,590 to the University of Wisconsin - Madison to characterize a novel mouse model with Alzheimer's disease-like tauopathy and neurodegeneration in the entorhinal cortex. The goal is to develop this mouse mutant into a unique animal model for studying the pathological mechanisms underlying Alzheimer's disease, particularly the interactions among amyloidosis, tauopathy, and...
This Project Grant award, totaling $442,357, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award is focused on elucidating the molecular mechanisms that give rise to functionally neurodegenerative microglia - the brain's primary innate immune cells - in Alzheimer's disease (AD). The key objectives are to: 1) determine the mechanisms of integrated stress response (ISR)-induced chromatin remodeling in microglia, 2) test...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the mechanisms by which loss of the polarity protein PAR3 contributes to Alzheimer's disease (AD) progression.
The $1,671,360 award to Rutgers, The State University of New Jersey, will test the hypotheses that PAR3 loss disrupts polarized...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $799,700 to University College London (UCL) to conduct a systems genetics analysis of resilience to tauopathy, a major component of Alzheimer's disease and related dementias (ADRD). The research aims to identify genetic factors that underlie resilience to tauopathy progression, which could represent novel therapeutic targets to prevent, delay, or treat frontotemporal dementia (FTD) and other...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $633,376 to Colorado State University to conduct research aimed at understanding how age-related declines in endosome formation contribute to the development of Alzheimer's disease (AD) and other protein-based neurodegenerative disorders. The key objectives are to: 1) Determine how increasing endosome formation can decrease pathological tau protein levels in neurons, and 2) Evaluate the impact...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD).
The project aims to develop new...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,061,909 to Weill Medical College of Cornell University to study the role of chaperone complexes in regulating tau protein aggregation and neurodegeneration in tauopathies, including Alzheimer's disease. The research aims to identify molecular mechanisms that either stabilize or target tau for degradation, with the goal of developing new therapeutic strategies for treating...