Project Grant R01NS150249
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $618,001 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate deuterium metabolic spectroscopy and imaging (DMS/I) as a technique for non-invasively measuring brain glucose and ketone metabolism in multiple sclerosis. The project uses deuterium-labeled metabolic tracers to investigate how energy...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $163,079 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on cerebrospinal fluid and skin biomarkers of cognitive decline in Parkinson disease and Lewy body dementia. The research validates candidate synaptic protein biomarkers (neuronal pentraxin 2 and somatostatin) in cerebrospinal fluid that may...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $232,836 on December 1, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop biomarkers of ischemic risk in adults with sickle cell disease using non-invasive quantitative neuroimaging methods. The research uses arterial spin labeling MRI and other quantitative imaging techniques to test hypotheses regarding cerebral oxygen utilization in patients with sickle cell disease...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Vanderbilt University Medical Center $711,408 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project, "Phenotypes and Endotypes of Recovery from Acute Disorders of Consciousness," pursues multimodal neurobiological prediction of recovery outcomes in...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $927,014 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to validate a diagnostic lipid biomarker panel for idiopathic Parkinson's disease. The R61 phase of this project will develop a quantitative liquid chromatography-mass spectrometry assay for eight lipid biomarkers discovered in red blood cells that distinguish idiopathic...
- This $427,625 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to the University of Washington aims to develop and optimize two novel blood-based biomarker assays to improve clinical diagnosis and differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA). The key products and services to be delivered under this 2-year grant include: Further development and optimization of a flow cytometry-based assay (APOGEE) to directly quantify...
- The National Institute of Neurological Disorders and Stroke, a division of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas Health Science Center at Houston $722,153 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R61NS151436). The recipient will develop and validate a seed amplification assay to detect alpha-synuclein...
- The National Institute of Neurological Disorders and Stroke awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $877,250 on May 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate aberrant M6A methylation correlating with hippocampal pathology in multiple sclerosis. The research examines how demyelination alters N6-methyladenosine (M6A) methylation patterns in gene transcripts...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $1.878 million to Mayo Clinic Jacksonville on September 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to interrogate alpha-synuclein aggregate-associated proteomes and identify modifiers of Lewy body disease. The project, running through August 31, 2029, employs...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $670,266 on January 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to map the epigenomic and spatial transcriptomic landscape in Parkinson's disease and Alzheimer's disease. The project characterizes shared and distinct transcriptional changes between Parkinson's disease, Alzheimer's disease, and Alzheimer's...
The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University Medical Center $444,336 on September 1, 2026, to establish and validate integrated imaging biomarkers for multiple system atrophy (MSA) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project develops and validates MRI-based biomarkers to improve diagnosis and enable monitoring of disease progression in patients with MSA, a rare, progressive, and fatal neurodegenerative disease currently without cure. The work focuses on the MSA Structural Index (MSA-SI), a composite volumetric score quantified from routine T1-weighted MRI, and complementary quantitative susceptibility mapping measures of brain iron, both of which have shown promise in single-site studies but require validation in larger, multi-site cohorts. Early and reliable biomarkers are critical to address early misdiagnosis due to symptom overlap with Parkinson's disease, which frequently delays patient qualification for clinical trials. Development of sensitive biomarkers would improve patient selection and monitoring for multiple disease-modifying MSA trials currently underway and expected in the next five years. The project runs from September 1, 2026, through May 31, 2031, with performance at Vanderbilt University Medical Center in Forest Hills, Tennessee. Work is classified as a Project Grant under the NINDS extramural research program supporting fundamental neuroscience research and investigations of neurological disease mechanisms and treatments.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.3k | 8/21/26 |