Project Grant R01NS146662
- The National Institute of Neurological Disorders and Stroke awarded Rutgers, The State University $118,593 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing). The award funds research investigating the role of dorsal horn interneurons expressing the serotonin 6 receptor (5HTR6+ interneurons) in sensorimotor integration within the spinal cord under both normal conditions and following spinal cord...
- The National Institute of Neurological Disorders and Stroke awarded the University of Southern California $181,891 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the RNA-regulatory activities of the RNA exosome during human motor neuron differentiation. The research examines how the RNA exosome, a post-transcriptional ribonuclease complex, regulates gene expression during stem cell differentiation...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $644,965 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate phylogenetic differences in motor neuron development between mouse and human systems. The research employs high-temporal resolution single-cell expression analysis and human induced pluripotent stem cell (hiPSC)...
- Federal Project Grant Award Summary Rutgers The State University of New Jersey received a $429,514 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded September 1, 2025, with completion anticipated by August 31, 2027. The research will be conducted at the institution's location in New Jersey and focuses on investigating myelin acquisition and...
- The National Institute of Neurological Disorders and Stroke awarded The Johns Hopkins University $131,569 on December 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of microglia in TRPV4-mediated motor neuron degeneration. The research characterizes specific subpopulations of microglia and determines their contributions to transient receptor potential vanilloid 4 (TRPV4)-mediated motor neuron...
- The National Institute of Neurological Disorders and Stroke awarded New Jersey Institute of Technology $553,292 on March 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to engineer an in vitro three-dimensional tissue construct for studying peripheral nerve regeneration. The recipient will develop 3D hollow channel systems seeded with embryonic dorsal root ganglia explants and coated with specific extracellular matrix...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $617,246 on September 26, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the toxicity of lipid-rich alpha-synuclein inclusions in Parkinson's disease pathology. The research examines Lewy bodies and related lipid-rich alpha-synuclein inclusions prevalent in the substantia nigra and brainstem regions....
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $639,875 on August 10, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R01NS151292). The recipient will characterize the molecular steps that allow post-mitotic neurons to correctly integrate into neural circuits, focusing on motor neurons that target adult leg muscles in...
- The National Institute on Aging awarded Rutgers The State University of New Jersey, School of Nursing, $431,750 on May 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of synaptojanin1 (SYNJ1) in age-dependent motor decline. The award funds research examining whether SYNJ1, a synaptic Parkinson's disease gene encoding a lipid phosphatase essential for synaptic membrane trafficking, contributes to normal age-related motor decline and whether targeting SYNJ1 can...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on March 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to exploit RNA biogenesis, specifically alternative splicing programs, to accelerate maturation of human neurons in vitro and to develop models of age-related tauopathies. The research addresses a fundamental...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded Rutgers The State University of New Jersey, School of Nursing, $474,749 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular and cellular mechanisms governing functional maturation and adult subtype diversification in spinal motor neurons. The project addresses postnatal maturation of skeletal motor neurons, which innervate muscles throughout the body to control movement. Adult motor neurons differentiate into three functionally distinct subtypes—alpha, gamma, and type 3/beta—that differ in morphology, electrophysiological properties, and circuit organization. These subtypes exhibit differential vulnerability to amyotrophic lateral sclerosis (ALS), with alpha motor neurons degenerating, gammas surviving, and the fate of type 3/beta neurons remaining unclear. The work will employ single-nuclei RNA and ATAC sequencing across embryonic, neonatal, juvenile, and adult mouse motor neurons to identify transcriptional regulators underlying adult subtype identity, including both subtype-specific and shared activity-dependent transcription factors. The research will utilize subtype-specific adeno-associated viral (AAV) tools to validate candidate regulatory mechanisms. Place of performance is Newark, New Jersey. The performance period runs August 1, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $474.7k | 7/30/26 |